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PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

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BACKGROUND: Microtubule-binding protein tau is a misfolding-prone protein associated with tauopathies. As tau undergoes cell-to-cell transmission, extracellular tau aggregates convert astrocytes into a pro-inflammatory state via integrin activation, causing them to release unknown neurotoxic factors...

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Detalles Bibliográficos
Autores principales:	Wang, Peng, Anderson, D. Eric, Ye, Yihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479431/ https://www.ncbi.nlm.nih.gov/pubmed/37674732 http://dx.doi.org/10.21203/rs.3.rs-3253118/v1

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