HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent

Parkinson disease (PD) is closely linked to the misfolding and accumulation of α-synuclein (α-syn) into Lewy bodies. HtrA1 is a PDZ serine protease that degrades fibrillar tau, which is associated with Alzheimer disease (AD). Further, inactivating mutations to mitochondrial HtrA2 have been implicate...

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Detalles Bibliográficos
Autores principales: Chen, Sheng, Puri, Anuradhika, Bell, Braxton, Fritsche, Joseph, Palacios, Hector, Balch, Maurie, Sprunger, Macy, Howard, Matthew, Patterson, Jessica, Patti, Gary, Davis, Albert, Jackrel, Meredith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479434/
https://www.ncbi.nlm.nih.gov/pubmed/37674720
http://dx.doi.org/10.21203/rs.3.rs-2570571/v1

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