Cargando…
Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study
BACKGROUND: There are insufficient studies on the effect of dietary salt intake on cardiovascular (CV) outcomes in chronic kidney disease (CKD) patients, and there is no consensus on the sodium (Na) intake level that increases the risk of CV disease in CKD patients. Therefore, we investigated the as...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479682/ https://www.ncbi.nlm.nih.gov/pubmed/37675361 http://dx.doi.org/10.3389/fneph.2023.1236177 |
_version_ | 1785101645710884864 |
---|---|
author | Kang, Seong Cheol Kang, Minjung Ryu, Hyunjin Kim, Seonmi Kim, Ji Hye Kang, Eunjeong Jeong, Yujin Kim, Jayoun Kim, Yong-Soo Kim, Soo Wan Kim, Yeong Hoon Oh, Kook-Hwan |
author_facet | Kang, Seong Cheol Kang, Minjung Ryu, Hyunjin Kim, Seonmi Kim, Ji Hye Kang, Eunjeong Jeong, Yujin Kim, Jayoun Kim, Yong-Soo Kim, Soo Wan Kim, Yeong Hoon Oh, Kook-Hwan |
author_sort | Kang, Seong Cheol |
collection | PubMed |
description | BACKGROUND: There are insufficient studies on the effect of dietary salt intake on cardiovascular (CV) outcomes in chronic kidney disease (CKD) patients, and there is no consensus on the sodium (Na) intake level that increases the risk of CV disease in CKD patients. Therefore, we investigated the association between dietary salt intake and CV outcomes in CKD patients. METHODS: In the Korean cohort study for Outcome in patients with CKD (KNOW-CKD), 1,937 patients were eligible for the study, and their dietary Na intake was estimated using measured 24h urinary Na excretion. The primary outcome was a composite of CV events and/or all-cause death. The secondary outcome was a major adverse cardiac event (MACE). RESULTS: Among 1,937 subjects, there were 205 (10.5%) events for the composite outcome and 110 (5.6%) events for MACE. Compared to the reference group (urinary Na excretion< 2.0g/day), the group with the highest measured 24h urinary Na excretion (urinary Na excretion ≥ 8.0g/day) was associated with increased risk of both the composite outcome (hazard ratio 3.29 [95% confidence interval 1.00-10.81]; P = 0.049) and MACE (hazard ratio 6.28 [95% confidence interval 1.45-27.20]; P = 0.013) in a cause-specific hazard model. Subgroup analysis also showed a pronounced association between dietary salt intake and the composite outcome in subgroups of patients with abdominal obesity, female, lower estimated glomerular filtration rate (< 60 ml/min per 1.73m(2)), no overt proteinuria, or a lower urinary potassium-to-creatinine ratio (< 46 mmol/g). CONCLUSION: A high-salt diet is associated with CV outcomes in non-dialysis CKD patients. |
format | Online Article Text |
id | pubmed-10479682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104796822023-09-06 Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study Kang, Seong Cheol Kang, Minjung Ryu, Hyunjin Kim, Seonmi Kim, Ji Hye Kang, Eunjeong Jeong, Yujin Kim, Jayoun Kim, Yong-Soo Kim, Soo Wan Kim, Yeong Hoon Oh, Kook-Hwan Front Nephrol Nephrology BACKGROUND: There are insufficient studies on the effect of dietary salt intake on cardiovascular (CV) outcomes in chronic kidney disease (CKD) patients, and there is no consensus on the sodium (Na) intake level that increases the risk of CV disease in CKD patients. Therefore, we investigated the association between dietary salt intake and CV outcomes in CKD patients. METHODS: In the Korean cohort study for Outcome in patients with CKD (KNOW-CKD), 1,937 patients were eligible for the study, and their dietary Na intake was estimated using measured 24h urinary Na excretion. The primary outcome was a composite of CV events and/or all-cause death. The secondary outcome was a major adverse cardiac event (MACE). RESULTS: Among 1,937 subjects, there were 205 (10.5%) events for the composite outcome and 110 (5.6%) events for MACE. Compared to the reference group (urinary Na excretion< 2.0g/day), the group with the highest measured 24h urinary Na excretion (urinary Na excretion ≥ 8.0g/day) was associated with increased risk of both the composite outcome (hazard ratio 3.29 [95% confidence interval 1.00-10.81]; P = 0.049) and MACE (hazard ratio 6.28 [95% confidence interval 1.45-27.20]; P = 0.013) in a cause-specific hazard model. Subgroup analysis also showed a pronounced association between dietary salt intake and the composite outcome in subgroups of patients with abdominal obesity, female, lower estimated glomerular filtration rate (< 60 ml/min per 1.73m(2)), no overt proteinuria, or a lower urinary potassium-to-creatinine ratio (< 46 mmol/g). CONCLUSION: A high-salt diet is associated with CV outcomes in non-dialysis CKD patients. Frontiers Media S.A. 2023-08-25 /pmc/articles/PMC10479682/ /pubmed/37675361 http://dx.doi.org/10.3389/fneph.2023.1236177 Text en Copyright © 2023 Kang, Kang, Ryu, Kim, Kim, Kang, Jeong, Kim, Kim, Kim, Kim and Oh https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nephrology Kang, Seong Cheol Kang, Minjung Ryu, Hyunjin Kim, Seonmi Kim, Ji Hye Kang, Eunjeong Jeong, Yujin Kim, Jayoun Kim, Yong-Soo Kim, Soo Wan Kim, Yeong Hoon Oh, Kook-Hwan Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study |
title | Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study |
title_full | Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study |
title_fullStr | Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study |
title_full_unstemmed | Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study |
title_short | Measured sodium excretion is associated with cardiovascular outcomes in non-dialysis CKD patients: results from the KNOW-CKD study |
title_sort | measured sodium excretion is associated with cardiovascular outcomes in non-dialysis ckd patients: results from the know-ckd study |
topic | Nephrology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479682/ https://www.ncbi.nlm.nih.gov/pubmed/37675361 http://dx.doi.org/10.3389/fneph.2023.1236177 |
work_keys_str_mv | AT kangseongcheol measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kangminjung measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT ryuhyunjin measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kimseonmi measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kimjihye measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kangeunjeong measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT jeongyujin measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kimjayoun measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kimyongsoo measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kimsoowan measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT kimyeonghoon measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy AT ohkookhwan measuredsodiumexcretionisassociatedwithcardiovascularoutcomesinnondialysisckdpatientsresultsfromtheknowckdstudy |