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Lactate metabolism in neurodegenerative diseases
Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions. T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479854/ https://www.ncbi.nlm.nih.gov/pubmed/37488846 http://dx.doi.org/10.4103/1673-5374.374142 |
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author | Yang, Chaoguang Pan, Rui-Yuan Guan, Fangxia Yuan, Zengqiang |
author_facet | Yang, Chaoguang Pan, Rui-Yuan Guan, Fangxia Yuan, Zengqiang |
author_sort | Yang, Chaoguang |
collection | PubMed |
description | Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions. The Astrocyte-Neuron Lactate Shuttle has clarified that lactate plays a pivotal role in the central nervous system. Moreover, protein lactylation highlights the novel role of lactate in regulating transcription, cellular functions, and disease development. This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases, thus providing optimal perspectives for future research. |
format | Online Article Text |
id | pubmed-10479854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-104798542023-09-06 Lactate metabolism in neurodegenerative diseases Yang, Chaoguang Pan, Rui-Yuan Guan, Fangxia Yuan, Zengqiang Neural Regen Res Review Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions. The Astrocyte-Neuron Lactate Shuttle has clarified that lactate plays a pivotal role in the central nervous system. Moreover, protein lactylation highlights the novel role of lactate in regulating transcription, cellular functions, and disease development. This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases, thus providing optimal perspectives for future research. Wolters Kluwer - Medknow 2023-04-20 /pmc/articles/PMC10479854/ /pubmed/37488846 http://dx.doi.org/10.4103/1673-5374.374142 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Yang, Chaoguang Pan, Rui-Yuan Guan, Fangxia Yuan, Zengqiang Lactate metabolism in neurodegenerative diseases |
title | Lactate metabolism in neurodegenerative diseases |
title_full | Lactate metabolism in neurodegenerative diseases |
title_fullStr | Lactate metabolism in neurodegenerative diseases |
title_full_unstemmed | Lactate metabolism in neurodegenerative diseases |
title_short | Lactate metabolism in neurodegenerative diseases |
title_sort | lactate metabolism in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479854/ https://www.ncbi.nlm.nih.gov/pubmed/37488846 http://dx.doi.org/10.4103/1673-5374.374142 |
work_keys_str_mv | AT yangchaoguang lactatemetabolisminneurodegenerativediseases AT panruiyuan lactatemetabolisminneurodegenerativediseases AT guanfangxia lactatemetabolisminneurodegenerativediseases AT yuanzengqiang lactatemetabolisminneurodegenerativediseases |