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Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models

Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic, physically debilitating neurological disorder. In addition to experiencing motor disability, patients with multiple sclerosis also experience a variety of non-motor sym...

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Autores principales: Weerasinghe-Mudiyanselage, Poornima D. E., Kim, Joong-Sun, Shin, Taekyun, Moon, Changjong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479859/
https://www.ncbi.nlm.nih.gov/pubmed/37488849
http://dx.doi.org/10.4103/1673-5374.375307
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author Weerasinghe-Mudiyanselage, Poornima D. E.
Kim, Joong-Sun
Shin, Taekyun
Moon, Changjong
author_facet Weerasinghe-Mudiyanselage, Poornima D. E.
Kim, Joong-Sun
Shin, Taekyun
Moon, Changjong
author_sort Weerasinghe-Mudiyanselage, Poornima D. E.
collection PubMed
description Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic, physically debilitating neurological disorder. In addition to experiencing motor disability, patients with multiple sclerosis also experience a variety of non-motor symptoms, including cognitive deficits, anxiety, depression, sensory impairments, and pain. However, the pathogenesis and treatment of such non-motor symptoms in multiple sclerosis are still under research. Preclinical studies for multiple sclerosis benefit from the use of disease-appropriate animal models, including experimental autoimmune encephalomyelitis. Prior to understanding the pathophysiology and developing treatments for non-motor symptoms, it is critical to characterize the animal model in terms of its ability to replicate certain non-motor features of multiple sclerosis. As such, no single animal model can mimic the entire spectrum of symptoms. This review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying mechanisms. Further, we highlighted gaps in the literature to explain the non-motor aspects of multiple sclerosis in experimental animal models, which will serve as the basis for future studies.
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spelling pubmed-104798592023-09-06 Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models Weerasinghe-Mudiyanselage, Poornima D. E. Kim, Joong-Sun Shin, Taekyun Moon, Changjong Neural Regen Res Review Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic, physically debilitating neurological disorder. In addition to experiencing motor disability, patients with multiple sclerosis also experience a variety of non-motor symptoms, including cognitive deficits, anxiety, depression, sensory impairments, and pain. However, the pathogenesis and treatment of such non-motor symptoms in multiple sclerosis are still under research. Preclinical studies for multiple sclerosis benefit from the use of disease-appropriate animal models, including experimental autoimmune encephalomyelitis. Prior to understanding the pathophysiology and developing treatments for non-motor symptoms, it is critical to characterize the animal model in terms of its ability to replicate certain non-motor features of multiple sclerosis. As such, no single animal model can mimic the entire spectrum of symptoms. This review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying mechanisms. Further, we highlighted gaps in the literature to explain the non-motor aspects of multiple sclerosis in experimental animal models, which will serve as the basis for future studies. Wolters Kluwer - Medknow 2023-05-31 /pmc/articles/PMC10479859/ /pubmed/37488849 http://dx.doi.org/10.4103/1673-5374.375307 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Weerasinghe-Mudiyanselage, Poornima D. E.
Kim, Joong-Sun
Shin, Taekyun
Moon, Changjong
Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models
title Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models
title_full Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models
title_fullStr Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models
title_full_unstemmed Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models
title_short Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models
title_sort understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479859/
https://www.ncbi.nlm.nih.gov/pubmed/37488849
http://dx.doi.org/10.4103/1673-5374.375307
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