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The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries. At present, no effective clinical treatment exists. As one of the artificial hibernation techniques, mild hypothermia has preliminarily confirmed its clinical...

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Autores principales: Liu, Caiyun, Yu, Haixin, Li, Zhengchao, Chen, Shulian, Li, Xiaoyin, Chen, Xuyi, Chen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479867/
https://www.ncbi.nlm.nih.gov/pubmed/37488839
http://dx.doi.org/10.4103/1673-5374.375305
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author Liu, Caiyun
Yu, Haixin
Li, Zhengchao
Chen, Shulian
Li, Xiaoyin
Chen, Xuyi
Chen, Bo
author_facet Liu, Caiyun
Yu, Haixin
Li, Zhengchao
Chen, Shulian
Li, Xiaoyin
Chen, Xuyi
Chen, Bo
author_sort Liu, Caiyun
collection PubMed
description Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries. At present, no effective clinical treatment exists. As one of the artificial hibernation techniques, mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury. However, its technical defects and barriers, along with serious clinical side effects, restrict its clinical application for spinal cord injury. Artificial hibernation is a future-oriented disruptive technology for human life support. It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons, reduce the central constant temperature setting point, disrupt the normal constant body temperature, make the body “adapt” to the external cold environment, and reduce the physiological resistance to cold stimulation. Thus, studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology. This review introduces artificial hibernation technologies, including mild hypothermia technology, hibernation inducers, and hibernation-related central neuromodulation technology. It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection. These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal cord injury through inflammatory inhibition, immunosuppression, oxidative defense, and possible central protection. It also promotes the repair and protection of respiratory and digestive, cardiovascular, locomotor, urinary, and endocrine systems. This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation. At present, artificial hibernation technology is not mature, and research faces various challenges. Nevertheless, the effort is worthwhile for the future development of medicine.
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spelling pubmed-104798672023-09-06 The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury Liu, Caiyun Yu, Haixin Li, Zhengchao Chen, Shulian Li, Xiaoyin Chen, Xuyi Chen, Bo Neural Regen Res Review Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries. At present, no effective clinical treatment exists. As one of the artificial hibernation techniques, mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury. However, its technical defects and barriers, along with serious clinical side effects, restrict its clinical application for spinal cord injury. Artificial hibernation is a future-oriented disruptive technology for human life support. It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons, reduce the central constant temperature setting point, disrupt the normal constant body temperature, make the body “adapt” to the external cold environment, and reduce the physiological resistance to cold stimulation. Thus, studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology. This review introduces artificial hibernation technologies, including mild hypothermia technology, hibernation inducers, and hibernation-related central neuromodulation technology. It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection. These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal cord injury through inflammatory inhibition, immunosuppression, oxidative defense, and possible central protection. It also promotes the repair and protection of respiratory and digestive, cardiovascular, locomotor, urinary, and endocrine systems. This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation. At present, artificial hibernation technology is not mature, and research faces various challenges. Nevertheless, the effort is worthwhile for the future development of medicine. Wolters Kluwer - Medknow 2023-05-31 /pmc/articles/PMC10479867/ /pubmed/37488839 http://dx.doi.org/10.4103/1673-5374.375305 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Liu, Caiyun
Yu, Haixin
Li, Zhengchao
Chen, Shulian
Li, Xiaoyin
Chen, Xuyi
Chen, Bo
The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury
title The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury
title_full The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury
title_fullStr The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury
title_full_unstemmed The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury
title_short The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury
title_sort future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479867/
https://www.ncbi.nlm.nih.gov/pubmed/37488839
http://dx.doi.org/10.4103/1673-5374.375305
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