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Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans
Ischemic myocardium cannot survive without reperfusion. However, reperfusion of the ischemic myocardium paradoxically induces myocyte death; this phenomenon is termed lethal reperfusion injury. To date, no effective approach has been demonstrated for ST-segment elevation myocardial infarction (STEMI...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480094/ https://www.ncbi.nlm.nih.gov/pubmed/36939958 http://dx.doi.org/10.1007/s12265-023-10372-y |
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author | Koyama, Takashi |
author_facet | Koyama, Takashi |
author_sort | Koyama, Takashi |
collection | PubMed |
description | Ischemic myocardium cannot survive without reperfusion. However, reperfusion of the ischemic myocardium paradoxically induces myocyte death; this phenomenon is termed lethal reperfusion injury. To date, no effective approach has been demonstrated for ST-segment elevation myocardial infarction (STEMI) in clinical settings. Recently, we demonstrated a novel approach for cardioprotection, termed postconditioning with lactate-enriched blood (PCLeB). PCLeB comprises intermittent reperfusion and timely coronary injections of lactated Ringer’s solution, which is implemented at the beginning of reperfusion. This approach is aimed at reducing lethal reperfusion injury via prolonging intracellular acidosis during the early period of reperfusion, compared with the original postconditioning protocol. Patients with STEMI treated using PCLeB have reported positive outcomes. This article represents an effort, with a perspective different from current insights, toward preventing lethal reperfusion injury, in light of the historical background of reperfusion injury research. PCLeB is considered the new approach for cardioprotection. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-10480094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-104800942023-09-07 Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans Koyama, Takashi J Cardiovasc Transl Res Review Ischemic myocardium cannot survive without reperfusion. However, reperfusion of the ischemic myocardium paradoxically induces myocyte death; this phenomenon is termed lethal reperfusion injury. To date, no effective approach has been demonstrated for ST-segment elevation myocardial infarction (STEMI) in clinical settings. Recently, we demonstrated a novel approach for cardioprotection, termed postconditioning with lactate-enriched blood (PCLeB). PCLeB comprises intermittent reperfusion and timely coronary injections of lactated Ringer’s solution, which is implemented at the beginning of reperfusion. This approach is aimed at reducing lethal reperfusion injury via prolonging intracellular acidosis during the early period of reperfusion, compared with the original postconditioning protocol. Patients with STEMI treated using PCLeB have reported positive outcomes. This article represents an effort, with a perspective different from current insights, toward preventing lethal reperfusion injury, in light of the historical background of reperfusion injury research. PCLeB is considered the new approach for cardioprotection. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2023-03-20 2023 /pmc/articles/PMC10480094/ /pubmed/36939958 http://dx.doi.org/10.1007/s12265-023-10372-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Koyama, Takashi Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans |
title | Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans |
title_full | Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans |
title_fullStr | Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans |
title_full_unstemmed | Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans |
title_short | Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans |
title_sort | postconditioning with lactate-enriched blood for reducing lethal reperfusion injury in humans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480094/ https://www.ncbi.nlm.nih.gov/pubmed/36939958 http://dx.doi.org/10.1007/s12265-023-10372-y |
work_keys_str_mv | AT koyamatakashi postconditioningwithlactateenrichedbloodforreducinglethalreperfusioninjuryinhumans |