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Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) is an essential eukaryotic enzyme and a validated drug target for combating malaria. However, previous PvNMT inhibitors ha...

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Detalles Bibliográficos
Autores principales:	Rodríguez-Hernández, Diego, Vijayan, Kamalakannan, Zigweid, Rachael, Fenwick, Michael K., Sankaran, Banumathi, Roobsoong, Wanlapa, Sattabongkot, Jetsumon, Glennon, Elizabeth K. K., Myler, Peter J., Sunnerhagen, Per, Staker, Bart L., Kaushansky, Alexis, Grøtli, Morten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480161/ https://www.ncbi.nlm.nih.gov/pubmed/37669940 http://dx.doi.org/10.1038/s41467-023-41119-7

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