Cargando…

Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) is an essential eukaryotic enzyme and a validated drug target for combating malaria. However, previous PvNMT inhibitors ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez-Hernández, Diego, Vijayan, Kamalakannan, Zigweid, Rachael, Fenwick, Michael K., Sankaran, Banumathi, Roobsoong, Wanlapa, Sattabongkot, Jetsumon, Glennon, Elizabeth K. K., Myler, Peter J., Sunnerhagen, Per, Staker, Bart L., Kaushansky, Alexis, Grøtli, Morten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480161/ https://www.ncbi.nlm.nih.gov/pubmed/37669940 http://dx.doi.org/10.1038/s41467-023-41119-7

Ejemplares similares

Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine
por: Flannery, Erika L., et al.
Publicado: (2022)

Identification of and Structural Insights into Hit Compounds Targeting N-Myristoyltransferase for Cryptosporidium Drug Development
por: Fenwick, Michael K., et al.
Publicado: (2023)

Characterization of the Tubovesicular Network in Plasmodium vivax Liver Stage Hypnozoites and Schizonts
por: Sylvester, Kayla, et al.
Publicado: (2021)

Mass Spectrometry Identification of Biomarkers in Extracellular Vesicles From Plasmodium vivax Liver Hypnozoite Infections
por: Gualdrón-López, Melisa, et al.
Publicado: (2022)

The challenges of Plasmodium vivax human malaria infection models for vaccine development
por: Roobsoong, Wanlapa, et al.
Publicado: (2023)

Liver-stage fate determination in Plasmodium vivax parasites: Characterization of schizont growth and hypnozoite fating from patient isolates
por: Vantaux, Amélie, et al.
Publicado: (2022)

Transmission efficiency of Plasmodium vivax at low parasitaemia
por: Surit, Thitiporn, et al.
Publicado: (2023)

Improvement of culture conditions for long-term in vitro culture of Plasmodium vivax
por: Roobsoong, Wanlapa, et al.
Publicado: (2015)

The Blood Stage Antigen RBP2-P1 of Plasmodium vivax Binds Reticulocytes and Is a Target of Naturally Acquired Immunity
por: Chim-Ong, Anongruk, et al.
Publicado: (2020)

Gene Models, Expression Repertoire, and Immune Response of Plasmodium vivax Reticulocyte Binding Proteins
por: Hietanen, Jenni, et al.
Publicado: (2016)

Overexpression of hepatocyte EphA2 enhances liver-stage infection by Plasmodium vivax
por: Chainarin, Sittinont, et al.
Publicado: (2022)

Hypnozoite depletion in successive Plasmodium vivax relapses
por: Noviyanti, Rintis, et al.
Publicado: (2022)

A rapid sensitive, flow cytometry-based method for the detection of Plasmodium vivax-infected blood cells
por: Roobsoong, Wanlapa, et al.
Publicado: (2014)

Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission
por: White, Michael T, et al.
Publicado: (2014)

Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates
por: Zhang, Yongzhe, et al.
Publicado: (2021)

Community acceptability, participation, and adherence to mass drug administration with primaquine for Plasmodium vivax elimination in Southern Thailand: a mixed methods approach
por: Saita, Sayambhu, et al.
Publicado: (2023)

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites
por: Maher, S. P., et al.
Publicado: (2023)

Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo
por: Adekunle, Adeshina I., et al.
Publicado: (2015)

Superinfection and the hypnozoite reservoir for Plasmodium vivax: a general framework
por: Mehra, Somya, et al.
Publicado: (2023)

Efficient synchronization of Plasmodium knowlesi in vitro cultures using guanidine hydrochloride
por: Ngernna, Sutharinee, et al.
Publicado: (2019)

Activation of the hypnozoite: a part of Plasmodium vivax life cycle and survival
por: Hulden, Lena, et al.
Publicado: (2011)

Multiple-Clone Activation of Hypnozoites Is the Leading Cause of Relapse in Plasmodium vivax Infection
por: de Araujo, Flávia Carolina F., et al.
Publicado: (2012)

Ethiopian Plasmodium vivax hypnozoites formation dynamics and their susceptibility to reference antimalarial drugs
por: Dembele, Laurent, et al.
Publicado: (2023)

Advancing Key Gaps in the Knowledge of Plasmodium vivax Cryptic Infections Using Humanized Mouse Models and Organs-on-Chips
por: Aparici Herraiz, Iris, et al.
Publicado: (2022)

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase
por: Rackham, Mark D., et al.
Publicado: (2012)

Prevalence of G6PD deficiency and diagnostic accuracy of a G6PD point-of-care test among a population at risk of malaria in Myanmar
por: Aung, Than Htike, et al.
Publicado: (2023)

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages
por: Schafer, Carola, et al.
Publicado: (2018)

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors
por: Schlott, Anja C., et al.
Publicado: (2019)

A large scale Plasmodium vivax- Saimiri boliviensis trophozoite-schizont transition proteome
por: Anderson, D. C., et al.
Publicado: (2017)

A glance of the blood stage transcriptome of a Southeast Asian Plasmodium ovale isolate
por: Brashear, Awtum M., et al.
Publicado: (2019)

Characterization of the Plasmodium vivax erythrocytic stage proteome and identification of a potent immunogenic antigen of the asexual stages
por: Roobsoong, Wanlapa, et al.
Publicado: (2010)

No more monkeying around: primate malaria model systems are key to understanding Plasmodium vivax liver-stage biology, hypnozoites, and relapses
por: Joyner, Chester, et al.
Publicado: (2015)

How radical is radical cure? Site-specific biases in clinical trials underestimate the effect of radical cure on Plasmodium vivax hypnozoites
por: Huber, John H., et al.
Publicado: (2021)

The Plasmodium vivax rhoptry neck protein 5 is expressed in the apical pole of Plasmodium vivax VCG-1 strain schizonts and binds to human reticulocytes
por: Arévalo-Pinzón, Gabriela, et al.
Publicado: (2015)

Case Report: Case Series of Human Plasmodium knowlesi Infection on the Southern Border of Thailand
por: Ngernna, Sutharinee, et al.
Publicado: (2019)

A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection
por: Schäfer, Carola, et al.
Publicado: (2020)

Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission
por: Kittichai, Veerayuth, et al.
Publicado: (2017)

Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1
por: Hietanen, Jenni, et al.
Publicado: (2021)

Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1,6-bisphosphate
por: Gardberg, Anna, et al.
Publicado: (2011)

Proteomic analysis of the Theileria annulata schizont
por: Witschi, M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_o46q3nd6lb5r04ldoj5d08d5nt