The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70

J-domain proteins tune the specificity of Hsp70s, engaging them in precise functions. Despite their essential role, the structure and function of many J-domain proteins remain largely unknown. We explore human DNAJA2, finding that it reversibly forms highly-ordered, tubular structures that can be di...

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Detalles Bibliográficos
Autores principales: Velasco-Carneros, Lorea, Cuéllar, Jorge, Dublang, Leire, Santiago, César, Maréchal, Jean-Didier, Martín-Benito, Jaime, Maestro, Moisés, Fernández-Higuero, José Ángel, Orozco, Natalia, Moro, Fernando, Valpuesta, José María, Muga, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480186/
https://www.ncbi.nlm.nih.gov/pubmed/37670029
http://dx.doi.org/10.1038/s41467-023-41150-8

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