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Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry
Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480211/ https://www.ncbi.nlm.nih.gov/pubmed/37669986 http://dx.doi.org/10.1038/s41467-023-41271-0 |
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| author | Kamiza, Abram Bunya Touré, Sounkou M. Zhou, Feng Soremekun, Opeyemi Cissé, Cheickna Wélé, Mamadou Touré, Aboubacrine M. Nashiru, Oyekanmi Corpas, Manuel Nyirenda, Moffat Crampin, Amelia Shaffer, Jeffrey Doumbia, Seydou Zeggini, Eleftheria Morris, Andrew P. Asimit, Jennifer L. Chikowore, Tinashe Fatumo, Segun |
| author_facet | Kamiza, Abram Bunya Touré, Sounkou M. Zhou, Feng Soremekun, Opeyemi Cissé, Cheickna Wélé, Mamadou Touré, Aboubacrine M. Nashiru, Oyekanmi Corpas, Manuel Nyirenda, Moffat Crampin, Amelia Shaffer, Jeffrey Doumbia, Seydou Zeggini, Eleftheria Morris, Andrew P. Asimit, Jennifer L. Chikowore, Tinashe Fatumo, Segun |
| author_sort | Kamiza, Abram Bunya |
| collection | PubMed |
| description | Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait fine-mapping (flashfm) in 125,000 individuals of African ancestry. Our meta-analysis and MTAG identified four and 14 novel loci associated with lipid traits, respectively. flashfm yielded an 18% mean reduction in the 99% credible set size compared to single-trait fine-mapping with JAM. Moreover, we identified more genetic variants with a posterior probability of causality >0.9 with flashfm than with JAM. In conclusion, we identified additional novel loci associated with lipid traits, and flashfm reduced the 99% credible set size to identify causal genetic variants associated with multiple lipid traits in African ancestry. |
| format | Online Article Text |
| id | pubmed-10480211 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104802112023-09-07 Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry Kamiza, Abram Bunya Touré, Sounkou M. Zhou, Feng Soremekun, Opeyemi Cissé, Cheickna Wélé, Mamadou Touré, Aboubacrine M. Nashiru, Oyekanmi Corpas, Manuel Nyirenda, Moffat Crampin, Amelia Shaffer, Jeffrey Doumbia, Seydou Zeggini, Eleftheria Morris, Andrew P. Asimit, Jennifer L. Chikowore, Tinashe Fatumo, Segun Nat Commun Article Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait fine-mapping (flashfm) in 125,000 individuals of African ancestry. Our meta-analysis and MTAG identified four and 14 novel loci associated with lipid traits, respectively. flashfm yielded an 18% mean reduction in the 99% credible set size compared to single-trait fine-mapping with JAM. Moreover, we identified more genetic variants with a posterior probability of causality >0.9 with flashfm than with JAM. In conclusion, we identified additional novel loci associated with lipid traits, and flashfm reduced the 99% credible set size to identify causal genetic variants associated with multiple lipid traits in African ancestry. Nature Publishing Group UK 2023-09-05 /pmc/articles/PMC10480211/ /pubmed/37669986 http://dx.doi.org/10.1038/s41467-023-41271-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Kamiza, Abram Bunya Touré, Sounkou M. Zhou, Feng Soremekun, Opeyemi Cissé, Cheickna Wélé, Mamadou Touré, Aboubacrine M. Nashiru, Oyekanmi Corpas, Manuel Nyirenda, Moffat Crampin, Amelia Shaffer, Jeffrey Doumbia, Seydou Zeggini, Eleftheria Morris, Andrew P. Asimit, Jennifer L. Chikowore, Tinashe Fatumo, Segun Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry |
| title | Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry |
| title_full | Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry |
| title_fullStr | Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry |
| title_full_unstemmed | Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry |
| title_short | Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry |
| title_sort | multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of african ancestry |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480211/ https://www.ncbi.nlm.nih.gov/pubmed/37669986 http://dx.doi.org/10.1038/s41467-023-41271-0 |
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