Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance

Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is u...

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Autores principales: Yin, Zixiao, Ma, Ruoyu, An, Qi, Xu, Yichen, Gan, Yifei, Zhu, Guanyu, Jiang, Yin, Zhang, Ning, Yang, Anchao, Meng, Fangang, Kühn, Andrea A., Bergman, Hagai, Neumann, Wolf-Julian, Zhang, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480217/
https://www.ncbi.nlm.nih.gov/pubmed/37669927
http://dx.doi.org/10.1038/s41467-023-41128-6
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author Yin, Zixiao
Ma, Ruoyu
An, Qi
Xu, Yichen
Gan, Yifei
Zhu, Guanyu
Jiang, Yin
Zhang, Ning
Yang, Anchao
Meng, Fangang
Kühn, Andrea A.
Bergman, Hagai
Neumann, Wolf-Julian
Zhang, Jianguo
author_facet Yin, Zixiao
Ma, Ruoyu
An, Qi
Xu, Yichen
Gan, Yifei
Zhu, Guanyu
Jiang, Yin
Zhang, Ning
Yang, Anchao
Meng, Fangang
Kühn, Andrea A.
Bergman, Hagai
Neumann, Wolf-Julian
Zhang, Jianguo
author_sort Yin, Zixiao
collection PubMed
description Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients.
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spelling pubmed-104802172023-09-07 Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance Yin, Zixiao Ma, Ruoyu An, Qi Xu, Yichen Gan, Yifei Zhu, Guanyu Jiang, Yin Zhang, Ning Yang, Anchao Meng, Fangang Kühn, Andrea A. Bergman, Hagai Neumann, Wolf-Julian Zhang, Jianguo Nat Commun Article Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients. Nature Publishing Group UK 2023-09-05 /pmc/articles/PMC10480217/ /pubmed/37669927 http://dx.doi.org/10.1038/s41467-023-41128-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yin, Zixiao
Ma, Ruoyu
An, Qi
Xu, Yichen
Gan, Yifei
Zhu, Guanyu
Jiang, Yin
Zhang, Ning
Yang, Anchao
Meng, Fangang
Kühn, Andrea A.
Bergman, Hagai
Neumann, Wolf-Julian
Zhang, Jianguo
Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
title Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
title_full Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
title_fullStr Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
title_full_unstemmed Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
title_short Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
title_sort pathological pallidal beta activity in parkinson’s disease is sustained during sleep and associated with sleep disturbance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480217/
https://www.ncbi.nlm.nih.gov/pubmed/37669927
http://dx.doi.org/10.1038/s41467-023-41128-6
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