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Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration

SVIL is a member of the villin/gelsolin superfamily and is responsible for encoding supervillin. It has been reported to be closely related to the occurrence and development of various tumors. However, the mechanism of SVIL in bladder cancer has not been reported yet. In this research, we evaluated...

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Autores principales: Nie, Zhenyu, Guo, Na, Peng, Yanling, Gao, Yuanhui, Cao, Hui, Zhang, Shufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480233/
https://www.ncbi.nlm.nih.gov/pubmed/37670039
http://dx.doi.org/10.1038/s41598-023-41759-1
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author Nie, Zhenyu
Guo, Na
Peng, Yanling
Gao, Yuanhui
Cao, Hui
Zhang, Shufang
author_facet Nie, Zhenyu
Guo, Na
Peng, Yanling
Gao, Yuanhui
Cao, Hui
Zhang, Shufang
author_sort Nie, Zhenyu
collection PubMed
description SVIL is a member of the villin/gelsolin superfamily and is responsible for encoding supervillin. It has been reported to be closely related to the occurrence and development of various tumors. However, the mechanism of SVIL in bladder cancer has not been reported yet. In this research, we evaluated the relationship between SVIL expression and bladder cancer in public dataset and examined the expression of SVIL in bladder cancer cell lines, tissue microarrays and patients in our cohort. Our work determined that the expression of SVIL in bladder cancer tissue was significantly lower than that in normal tissue. However, in bladder cancer tissues, the high expression of SVIL is significantly associated with poor prognosis. This kind of duality is very novel and has great research value. The expression level of SVIL can well predict the survival time of bladder cancer patients, and is an independent risk factor of bladder cancer patients. The expression of SVIL is also closely related to the immune tumor microenvironment of bladder cancer. Our research provides a basis for personalized therapeutic targets for bladder cancer.
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spelling pubmed-104802332023-09-07 Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration Nie, Zhenyu Guo, Na Peng, Yanling Gao, Yuanhui Cao, Hui Zhang, Shufang Sci Rep Article SVIL is a member of the villin/gelsolin superfamily and is responsible for encoding supervillin. It has been reported to be closely related to the occurrence and development of various tumors. However, the mechanism of SVIL in bladder cancer has not been reported yet. In this research, we evaluated the relationship between SVIL expression and bladder cancer in public dataset and examined the expression of SVIL in bladder cancer cell lines, tissue microarrays and patients in our cohort. Our work determined that the expression of SVIL in bladder cancer tissue was significantly lower than that in normal tissue. However, in bladder cancer tissues, the high expression of SVIL is significantly associated with poor prognosis. This kind of duality is very novel and has great research value. The expression level of SVIL can well predict the survival time of bladder cancer patients, and is an independent risk factor of bladder cancer patients. The expression of SVIL is also closely related to the immune tumor microenvironment of bladder cancer. Our research provides a basis for personalized therapeutic targets for bladder cancer. Nature Publishing Group UK 2023-09-05 /pmc/articles/PMC10480233/ /pubmed/37670039 http://dx.doi.org/10.1038/s41598-023-41759-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nie, Zhenyu
Guo, Na
Peng, Yanling
Gao, Yuanhui
Cao, Hui
Zhang, Shufang
Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration
title Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration
title_full Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration
title_fullStr Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration
title_full_unstemmed Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration
title_short Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration
title_sort duality of the svil expression in bladder cancer and its correlation with immune infiltration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480233/
https://www.ncbi.nlm.nih.gov/pubmed/37670039
http://dx.doi.org/10.1038/s41598-023-41759-1
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