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Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies

The incidence of Clostridioides difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. Here we report on the development of mRNA-LNPs encoding camelid-derived V(H)H-based neutralizing agents (VN...

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Detalles Bibliográficos
Autores principales:	Thran, Moritz, Pönisch, Marion, Danz, Hillary, Horscroft, Nigel, Ichtchenko, Konstantin, Tzipori, Saul, Shoemaker, Charles B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480410/ https://www.ncbi.nlm.nih.gov/pubmed/37670025 http://dx.doi.org/10.1038/s41598-023-41092-7

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