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A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage

BACKGROUND: Disseminated intravascular coagulation (DIC) has been reported in various solid malignancies and is a common coagulation‐related complication in prostate cancer. However, DIC has been rarely reported as the initial presentation of prostate cancer. Herein, we reported a patient referring...

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Autores principales: Shafie, Mahan, Shahmohamadi, Elnaz, Hadizadeh, Alireza, Hasanzadeh, Alireza, Gholampour, Golsa, Parsa, Samaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480424/
https://www.ncbi.nlm.nih.gov/pubmed/37435692
http://dx.doi.org/10.1002/cnr2.1868
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author Shafie, Mahan
Shahmohamadi, Elnaz
Hadizadeh, Alireza
Hasanzadeh, Alireza
Gholampour, Golsa
Parsa, Samaneh
author_facet Shafie, Mahan
Shahmohamadi, Elnaz
Hadizadeh, Alireza
Hasanzadeh, Alireza
Gholampour, Golsa
Parsa, Samaneh
author_sort Shafie, Mahan
collection PubMed
description BACKGROUND: Disseminated intravascular coagulation (DIC) has been reported in various solid malignancies and is a common coagulation‐related complication in prostate cancer. However, DIC has been rarely reported as the initial presentation of prostate cancer. Herein, we reported a patient referring with subdural hemorrhage (SDH) and DIC with an unexplained cause who was later diagnosed with prostate cancer. CASE PRESENTATION: We presented a 68‐year‐old man who was referred to the hospital with a gradual deterioration of consciousness, dyspnea, and edema in the genitalia and lower limbs. His primary laboratory tests showed elevated prothrombin time (PT) and partial thromboplastin time (PTT) and a decreased fibrinogen level of 47 mg/dL [200–400 mg/dL]. The DIC score was 7, which was suggestive of DIC. Moreover, cranial imaging showed SDH. Further work‐up revealed elevated prostate‐specific antigen and prostate enlargement with a mass effect on the bladder with a bone lesion, which was suggestive of metastatic prostate cancer. CONCLUSION: This report highlights DIC as a possible initial presentation of an underlying malignancy, as well as the importance of treatment of underlying disease in the management of DIC. A comprehensive and systematic work‐up is essential for early diagnosis in patients with DIC to avoid further complications and mortality.
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spelling pubmed-104804242023-09-07 A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage Shafie, Mahan Shahmohamadi, Elnaz Hadizadeh, Alireza Hasanzadeh, Alireza Gholampour, Golsa Parsa, Samaneh Cancer Rep (Hoboken) Case Reports BACKGROUND: Disseminated intravascular coagulation (DIC) has been reported in various solid malignancies and is a common coagulation‐related complication in prostate cancer. However, DIC has been rarely reported as the initial presentation of prostate cancer. Herein, we reported a patient referring with subdural hemorrhage (SDH) and DIC with an unexplained cause who was later diagnosed with prostate cancer. CASE PRESENTATION: We presented a 68‐year‐old man who was referred to the hospital with a gradual deterioration of consciousness, dyspnea, and edema in the genitalia and lower limbs. His primary laboratory tests showed elevated prothrombin time (PT) and partial thromboplastin time (PTT) and a decreased fibrinogen level of 47 mg/dL [200–400 mg/dL]. The DIC score was 7, which was suggestive of DIC. Moreover, cranial imaging showed SDH. Further work‐up revealed elevated prostate‐specific antigen and prostate enlargement with a mass effect on the bladder with a bone lesion, which was suggestive of metastatic prostate cancer. CONCLUSION: This report highlights DIC as a possible initial presentation of an underlying malignancy, as well as the importance of treatment of underlying disease in the management of DIC. A comprehensive and systematic work‐up is essential for early diagnosis in patients with DIC to avoid further complications and mortality. John Wiley and Sons Inc. 2023-07-12 /pmc/articles/PMC10480424/ /pubmed/37435692 http://dx.doi.org/10.1002/cnr2.1868 Text en © 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Shafie, Mahan
Shahmohamadi, Elnaz
Hadizadeh, Alireza
Hasanzadeh, Alireza
Gholampour, Golsa
Parsa, Samaneh
A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
title A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
title_full A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
title_fullStr A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
title_full_unstemmed A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
title_short A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
title_sort rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480424/
https://www.ncbi.nlm.nih.gov/pubmed/37435692
http://dx.doi.org/10.1002/cnr2.1868
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