Expression of NORAD correlates with breast cancer aggressiveness and protects breast cancer cells from chemotherapy

The recently discovered human lncRNA NORAD is induced after DNA damage in a p53-dependent manner. It plays a critical role in the maintenance of genomic stability through interaction with Pumilio proteins, limiting the repression of their target mRNAs. Therefore, NORAD inactivation causes chromosoma...

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Detalles Bibliográficos
Autores principales: Alves-Vale, Catarina, Capela, Ana Maria, Tavares-Marcos, Carlota, Domingues-Silva, Beatriz, Pereira, Bruno, Santos, Francisco, Gomes, Carla Pereira, Espadas, Guadalupe, Vitorino, Rui, Sabidó, Eduard, Borralho, Paula, Nóbrega-Pereira, Sandrina, Bernardes de Jesus, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480464/
https://www.ncbi.nlm.nih.gov/pubmed/37680988
http://dx.doi.org/10.1016/j.omtn.2023.08.019

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