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Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women

Overweight and obesity rates have increased in recent decades, particularly among the younger population. The long-term consequences of obesity with respect to early venous thromboembolism (VTE) in women have not been established. The aim was to investigate the association between body mass index (B...

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Autores principales: Mahmoud, Ahmad, Sandblad, Katarina Glise, Lundberg, Christina E., Hellsén, Gustaf, Hansson, Per Olof, Adiels, Martin, Rosengren, Annika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480468/
https://www.ncbi.nlm.nih.gov/pubmed/37670016
http://dx.doi.org/10.1038/s41598-023-41186-2
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author Mahmoud, Ahmad
Sandblad, Katarina Glise
Lundberg, Christina E.
Hellsén, Gustaf
Hansson, Per Olof
Adiels, Martin
Rosengren, Annika
author_facet Mahmoud, Ahmad
Sandblad, Katarina Glise
Lundberg, Christina E.
Hellsén, Gustaf
Hansson, Per Olof
Adiels, Martin
Rosengren, Annika
author_sort Mahmoud, Ahmad
collection PubMed
description Overweight and obesity rates have increased in recent decades, particularly among the younger population. The long-term consequences of obesity with respect to early venous thromboembolism (VTE) in women have not been established. The aim was to investigate the association between body mass index (BMI) in early pregnancy as a proxy for non-pregnant weight and long-term post-pregnancy risk of VTE in women. This registry-based prospective cohort study analysed data from the Swedish Medical Birth Registry, linked to the National Patient and the National Cause of Death Registries for information on post-pregnancy long-term risk of VTE. Cox proportional hazards model were used to determine the association between BMI at baseline and VTE events during follow-up starting 1 year after baseline. The mean age at registration was 27.5 (standard deviation, 4.9) years. During a median follow-up duration of 12 years (interquartile range, 6–21 years) starting 1 year after the first antenatal visit, 1765 and 2549 women had a deep vein thrombosis and/or pulmonary embolism. The risk of VTE linearly increased with increasing BMI. Compared to women with 20 ≤ BMI < 22.5 kg/m(2), women with high normal weight, i.e. with a BMI of 22.5–25.0 kg/m(2), had an adjusted hazard ratio (HR) of 1.30 (95% confidence interval [CI] 1.19–1.41), whereas those with a BMI of 30–35 kg/m(2) and ≥ 35 kg/m(2) (severe obesity) had an adjusted HR of 2.35 (95% CI 2.04–2.70) and 3.47 (95% CI 2.82–4.25, respectively. Using BMI in early pregnancy as a proxy for pre-pregnancy or non-pregnant BMI in young women, we found a significantly increased risk of post-pregnancy long-term risk of VTE even in those with high normal BMI, compared with lean women, whereas those with severe obesity had a markedly high risk.
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spelling pubmed-104804682023-09-07 Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women Mahmoud, Ahmad Sandblad, Katarina Glise Lundberg, Christina E. Hellsén, Gustaf Hansson, Per Olof Adiels, Martin Rosengren, Annika Sci Rep Article Overweight and obesity rates have increased in recent decades, particularly among the younger population. The long-term consequences of obesity with respect to early venous thromboembolism (VTE) in women have not been established. The aim was to investigate the association between body mass index (BMI) in early pregnancy as a proxy for non-pregnant weight and long-term post-pregnancy risk of VTE in women. This registry-based prospective cohort study analysed data from the Swedish Medical Birth Registry, linked to the National Patient and the National Cause of Death Registries for information on post-pregnancy long-term risk of VTE. Cox proportional hazards model were used to determine the association between BMI at baseline and VTE events during follow-up starting 1 year after baseline. The mean age at registration was 27.5 (standard deviation, 4.9) years. During a median follow-up duration of 12 years (interquartile range, 6–21 years) starting 1 year after the first antenatal visit, 1765 and 2549 women had a deep vein thrombosis and/or pulmonary embolism. The risk of VTE linearly increased with increasing BMI. Compared to women with 20 ≤ BMI < 22.5 kg/m(2), women with high normal weight, i.e. with a BMI of 22.5–25.0 kg/m(2), had an adjusted hazard ratio (HR) of 1.30 (95% confidence interval [CI] 1.19–1.41), whereas those with a BMI of 30–35 kg/m(2) and ≥ 35 kg/m(2) (severe obesity) had an adjusted HR of 2.35 (95% CI 2.04–2.70) and 3.47 (95% CI 2.82–4.25, respectively. Using BMI in early pregnancy as a proxy for pre-pregnancy or non-pregnant BMI in young women, we found a significantly increased risk of post-pregnancy long-term risk of VTE even in those with high normal BMI, compared with lean women, whereas those with severe obesity had a markedly high risk. Nature Publishing Group UK 2023-09-05 /pmc/articles/PMC10480468/ /pubmed/37670016 http://dx.doi.org/10.1038/s41598-023-41186-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mahmoud, Ahmad
Sandblad, Katarina Glise
Lundberg, Christina E.
Hellsén, Gustaf
Hansson, Per Olof
Adiels, Martin
Rosengren, Annika
Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women
title Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women
title_full Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women
title_fullStr Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women
title_full_unstemmed Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women
title_short Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women
title_sort prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480468/
https://www.ncbi.nlm.nih.gov/pubmed/37670016
http://dx.doi.org/10.1038/s41598-023-41186-2
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