Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

Volume-regulated anion channels (VRACs) are hexamers of LRRC8 proteins that are crucial for cell volume regulation. N termini (NTs) of the obligatory LRRC8A subunit modulate VRACs activation and ion selectivity, but the underlying mechanisms remain poorly understood. Here, we report a 2.8-Å cryo-ele...

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Detalles Bibliográficos
Autores principales: Liu, Heng, Polovitskaya, Maya M., Yang, Linlin, Li, Meiling, Li, Hongyue, Han, Zhen, Wu, Jianguo, Zhang, Qiansen, Jentsch, Thomas J., Liao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480491/
https://www.ncbi.nlm.nih.gov/pubmed/37543949
http://dx.doi.org/10.1016/j.celrep.2023.112926

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