4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway during neurodevelopment leads to focal cortical malformations associated with intractable seizures. Recent evidence suggests that dysregulated cap-dependent translation downstream of mTORC1 contributes to cytoarchitect...

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Detalles Bibliográficos
Autores principales: Nguyen, Lena H., Sharma, Manas, Bordey, Angelique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480503/
https://www.ncbi.nlm.nih.gov/pubmed/37680968
http://dx.doi.org/10.3389/fnins.2023.1257056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480503/
https://www.ncbi.nlm.nih.gov/pubmed/37680968
http://dx.doi.org/10.3389/fnins.2023.1257056

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