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Risk factors for anemia of prematurity among 30-35-week preterm infants
BACKGROUND: The risk factors for anemia of prematurity (AOP) among late preterm infants are unelucidated. We identified risk factors for declining hemoglobin (Hb) concentration and triggering factors for AOP treatment in infants born at 30-35 gestational weeks. METHODS: From 2012 to 2020, we conduct...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Fukushima Society of Medical Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480510/ https://www.ncbi.nlm.nih.gov/pubmed/37164765 http://dx.doi.org/10.5387/fms.2022-21 |
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author | Kitaoka, Hiroki Shitara, Yoshihiko Kashima, Kohei Ochiai, Shingo Chikai, Hayato Watanabe, Keiko Ida, Hiroto Kumagai, Tadayuki Takahashi, Naoto |
author_facet | Kitaoka, Hiroki Shitara, Yoshihiko Kashima, Kohei Ochiai, Shingo Chikai, Hayato Watanabe, Keiko Ida, Hiroto Kumagai, Tadayuki Takahashi, Naoto |
author_sort | Kitaoka, Hiroki |
collection | PubMed |
description | BACKGROUND: The risk factors for anemia of prematurity (AOP) among late preterm infants are unelucidated. We identified risk factors for declining hemoglobin (Hb) concentration and triggering factors for AOP treatment in infants born at 30-35 gestational weeks. METHODS: From 2012 to 2020, we conducted a single-center retrospective study of infants born at 30-35 weeks of gestation without congenital anomalies or severe hemorrhage. The primary outcome was AOP development, defined by initiation of treatments including red blood cell transfusion, subcutaneous injections of erythropoietin, and iron supplementation. A multivariable logistic regression model was used to investigate potential risk factors for AOP. RESULTS: A total of 358 infants were included. Lower gestational age (odds ratio, 0.19; 95% confidence interval 0.11-0.32), small for gestational age (SGA; 7.17, 2.15-23.9), low maternal Hb level before birth (0.66, 0.49-0.87), low Hb at birth (0.71, 0.57-0.89), and multiple large blood samplings (1.79; 1.40-2.29) showed significantly higher odds for AOP development. CONCLUSIONS: Gestational age, SGA, low maternal Hb before birth, Hb at birth, and high number of large blood samplings were positively associated with AOP development in infants born at 30-35 gestational weeks. |
format | Online Article Text |
id | pubmed-10480510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Fukushima Society of Medical Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104805102023-09-07 Risk factors for anemia of prematurity among 30-35-week preterm infants Kitaoka, Hiroki Shitara, Yoshihiko Kashima, Kohei Ochiai, Shingo Chikai, Hayato Watanabe, Keiko Ida, Hiroto Kumagai, Tadayuki Takahashi, Naoto Fukushima J Med Sci Original Article BACKGROUND: The risk factors for anemia of prematurity (AOP) among late preterm infants are unelucidated. We identified risk factors for declining hemoglobin (Hb) concentration and triggering factors for AOP treatment in infants born at 30-35 gestational weeks. METHODS: From 2012 to 2020, we conducted a single-center retrospective study of infants born at 30-35 weeks of gestation without congenital anomalies or severe hemorrhage. The primary outcome was AOP development, defined by initiation of treatments including red blood cell transfusion, subcutaneous injections of erythropoietin, and iron supplementation. A multivariable logistic regression model was used to investigate potential risk factors for AOP. RESULTS: A total of 358 infants were included. Lower gestational age (odds ratio, 0.19; 95% confidence interval 0.11-0.32), small for gestational age (SGA; 7.17, 2.15-23.9), low maternal Hb level before birth (0.66, 0.49-0.87), low Hb at birth (0.71, 0.57-0.89), and multiple large blood samplings (1.79; 1.40-2.29) showed significantly higher odds for AOP development. CONCLUSIONS: Gestational age, SGA, low maternal Hb before birth, Hb at birth, and high number of large blood samplings were positively associated with AOP development in infants born at 30-35 gestational weeks. The Fukushima Society of Medical Science 2023-05-11 2023 /pmc/articles/PMC10480510/ /pubmed/37164765 http://dx.doi.org/10.5387/fms.2022-21 Text en © 2023 The Fukushima Society of Medical Science https://creativecommons.org/licenses/by-nc-sa/4.0/This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. https://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Original Article Kitaoka, Hiroki Shitara, Yoshihiko Kashima, Kohei Ochiai, Shingo Chikai, Hayato Watanabe, Keiko Ida, Hiroto Kumagai, Tadayuki Takahashi, Naoto Risk factors for anemia of prematurity among 30-35-week preterm infants |
title | Risk factors for anemia of prematurity among 30-35-week preterm infants |
title_full | Risk factors for anemia of prematurity among 30-35-week preterm infants |
title_fullStr | Risk factors for anemia of prematurity among 30-35-week preterm infants |
title_full_unstemmed | Risk factors for anemia of prematurity among 30-35-week preterm infants |
title_short | Risk factors for anemia of prematurity among 30-35-week preterm infants |
title_sort | risk factors for anemia of prematurity among 30-35-week preterm infants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480510/ https://www.ncbi.nlm.nih.gov/pubmed/37164765 http://dx.doi.org/10.5387/fms.2022-21 |
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