Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease

BACKGROUND: Dysregulated inflammatory responses and oxidative stress are key pathogenic drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells (Tregs) are essential to prevent excessive immune activation and maintain tissue homeostasis. While inflammatory cues are...

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Detalles Bibliográficos
Autores principales: Vaikunthanathan, Trishan, Landmann, Emmanuelle, Correa, Diana Marin, Romano, Marco, Trevelin, Silvia Cellone, Peng, Qi, Crespo, Elena, Corrado, Mauro, Lozano, Juan-José, Pearce, Erika L., Perpinan, Elena, Zoccarato, Anna, Siew, Leonard, Edwards-Hicks, Joy, Khan, Reenam, Luu, Nguyet-Thin, Thursz, Mark R., Newsome, Philip N., Martinez-Llordella, Marc, Shah, Naina, Lechler, Robert I., Shah, Ajay M., Sanchez-Fueyo, Alberto, Lombardi, Giovanna, Safinia, Niloufar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480539/
https://www.ncbi.nlm.nih.gov/pubmed/37657135
http://dx.doi.org/10.1016/j.ebiom.2023.104778

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