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ssDNA reeling is an intermediate step in the reiterative DNA unwinding activity of the WRN-1 helicase
RecQ helicases are highly conserved between bacteria and humans. These helicases unwind various DNA structures in the 3′ to 5′. Defective helicase activity elevates genomic instability and is associated with predisposition to cancer and/or premature aging. Recent single-molecule analyses have reveal...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480542/ https://www.ncbi.nlm.nih.gov/pubmed/37495105 http://dx.doi.org/10.1016/j.jbc.2023.105081 |