Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models

Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene have been identified as one of the most common genetic causes of Parkinson’s disease (PD). The LRRK2 PD-associated mutations LRRK2(G2019S) and LRRK2(R1441C), located in the kinase domain and in the ROC-COR domain, respectively, have been dem...

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Detalles Bibliográficos
Autores principales: Williamson, Matthew G, Madureira, Marta, McGuinness, William, Heon-Roberts, Rachel, Mock, Elliot D, Naidoo, Kalina, Cramb, Kaitlyn M L, Caiazza, Maria-Claudia, Malpartida, Ana B, Lavelle, Martha, Savory, Katrina, Humble, Stewart W, Patterson, Ryan, Davis, John B, Connor-Robson, Natalie, Ryan, Brent J, Wade-Martins, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481106/
https://www.ncbi.nlm.nih.gov/pubmed/37384414
http://dx.doi.org/10.1093/hmg/ddad102

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