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Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action

Chemodynamic therapy (CDT) has received more and more attention as an emerging therapeutic strategy, especially transition metals with Fenton or Fenton-like activity have good effects in CDT research, manganese dioxide nanosheets (MnO(2) NSs) and their complexes have become one of the most favored n...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Wen, Changchun, Hu, Miaomiao, Long, Juan, Zhang, Jing, Li, Minzhe, Lin, Xiang-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481133/
https://www.ncbi.nlm.nih.gov/pubmed/37681048
http://dx.doi.org/10.1039/d3ra03992g
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author Liu, Jian
Wen, Changchun
Hu, Miaomiao
Long, Juan
Zhang, Jing
Li, Minzhe
Lin, Xiang-Cheng
author_facet Liu, Jian
Wen, Changchun
Hu, Miaomiao
Long, Juan
Zhang, Jing
Li, Minzhe
Lin, Xiang-Cheng
author_sort Liu, Jian
collection PubMed
description Chemodynamic therapy (CDT) has received more and more attention as an emerging therapeutic strategy, especially transition metals with Fenton or Fenton-like activity have good effects in CDT research, manganese dioxide nanosheets (MnO(2) NSs) and their complexes have become one of the most favored nanomaterials in CDT of tumors. CDT is mainly based on the role of reactive oxygen species (ROS) in tumor treatment, which have clear chemical properties and produce clear chemical reactions. However, their mechanism of interaction with cells has not been fully elucidated. Here, we performed CDT on mouse breast cancer cells (4T1) based on MnO(2) NSs, extracted the metabolites from the 4T1 cells during the treatment, and analyzed the differences in metabolites by using high-resolution liquid chromatography-mass spectrometry (LC-MS). Untargeted metabolomics studies were conducted using the relevant data. This study mainly explored the changes in MnO(2) NSs on the metabolite profile of 4T1 cells and their potential impact on tumor therapy, in order to determine the mechanism of action of MnO(2) NSs in the treatment of breast cancer. The results of the study showed the presence of 11 different metabolites in MnO(2) NSs CDT for 4T1 tumor cells, including phosphoserine, sphingine, phosphocholine, and stearoylcarnitine. These findings provide a deeper understanding of breast cancer treatment, and are beneficial for the further research and clinical application of CDT.
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spelling pubmed-104811332023-09-07 Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action Liu, Jian Wen, Changchun Hu, Miaomiao Long, Juan Zhang, Jing Li, Minzhe Lin, Xiang-Cheng RSC Adv Chemistry Chemodynamic therapy (CDT) has received more and more attention as an emerging therapeutic strategy, especially transition metals with Fenton or Fenton-like activity have good effects in CDT research, manganese dioxide nanosheets (MnO(2) NSs) and their complexes have become one of the most favored nanomaterials in CDT of tumors. CDT is mainly based on the role of reactive oxygen species (ROS) in tumor treatment, which have clear chemical properties and produce clear chemical reactions. However, their mechanism of interaction with cells has not been fully elucidated. Here, we performed CDT on mouse breast cancer cells (4T1) based on MnO(2) NSs, extracted the metabolites from the 4T1 cells during the treatment, and analyzed the differences in metabolites by using high-resolution liquid chromatography-mass spectrometry (LC-MS). Untargeted metabolomics studies were conducted using the relevant data. This study mainly explored the changes in MnO(2) NSs on the metabolite profile of 4T1 cells and their potential impact on tumor therapy, in order to determine the mechanism of action of MnO(2) NSs in the treatment of breast cancer. The results of the study showed the presence of 11 different metabolites in MnO(2) NSs CDT for 4T1 tumor cells, including phosphoserine, sphingine, phosphocholine, and stearoylcarnitine. These findings provide a deeper understanding of breast cancer treatment, and are beneficial for the further research and clinical application of CDT. The Royal Society of Chemistry 2023-09-06 /pmc/articles/PMC10481133/ /pubmed/37681048 http://dx.doi.org/10.1039/d3ra03992g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Jian
Wen, Changchun
Hu, Miaomiao
Long, Juan
Zhang, Jing
Li, Minzhe
Lin, Xiang-Cheng
Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action
title Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action
title_full Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action
title_fullStr Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action
title_full_unstemmed Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action
title_short Metabolomics analysis of MnO(2) nanosheets CDT for breast cancer cells and mechanism of cytotoxic action
title_sort metabolomics analysis of mno(2) nanosheets cdt for breast cancer cells and mechanism of cytotoxic action
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481133/
https://www.ncbi.nlm.nih.gov/pubmed/37681048
http://dx.doi.org/10.1039/d3ra03992g
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