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clifford (B.4.1) , an allele of CG1603 , causes tissue overgrowth in the Drosophila melanogaster eye
Mutant B.4.1 , generated via EMS mutagenesis in Drosophila melanogaster , was studied by undergraduate students participating in the Fly-CURE. After inducing genetically mosaic tissue in the adult eye, B.4.1 mutant tissue displays a robust increase in cell division and a rough appearance. Complement...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Caltech Library
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481159/ https://www.ncbi.nlm.nih.gov/pubmed/37680216 http://dx.doi.org/10.17912/micropub.biology.000936 |
| _version_ | 1785101914001637376 |
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| author | Nowaskie, Reagan R Kitch, Ashley Adams, Abby Anandaraj, Abinaya Apawan, Ethan Bañuelos, Liliana Betz, Cassandra J Bogunia, Julia M Buechlein, Nicholas Burns, Morgan R Collier, Hayley A Collins, Zach Combs, Kynzie Dakarian, Vana D Daniel, Abigail De Jesus III, Conrad M Erickson, John D Estrada, Bianca Estrada, Kevin Fields, Sydney Gabriel, Maya Garcia, Rosario M Gitamo, Sylvia Granath, Emma Hardin, Sabrina N Hattling, Emily Henriquez, Alexandra VL Hernandez, Destiny Johnson, Luke Kim, Annie H Kolley, Lillian K Larue, Katelynn M Lockwood, Erin Longoria, Nelia Lopez, Cassandra Lopez-Roca Fernandez, Rosario C Lozano, Sofia Manthie, Carissa May, Trinity Mehrzad, Zorah Mendoza, Itzel Mohan, Somya Mounthachak, Claylan Muyizere, Merveille Myers, Margaret R Newton, Jayce Nwawueze, Amarachi Paredes, Ariana J Pezdek, Marissa N Phat Nguyen, Hoang Pobuda, Nadia Sadat, Sahar Sailor, Johnathon J Santiago, David Sbarbaro, Madison Schultz III, David E Senobari, Anahita N Shouse, Emma M Snarski, Sarah M Solano, Estefanie Solis Campos, Naomi Stewart, Elnora Szczepaniak, Jessica Tejeda, Michael Teoli, Dominic F Tran, Michael Trivedi, Nishita Uribe Aristizabal, Laurita Vargas, Bryan Z Walker III, Kenneth W Wasiqi, Joseph Wong, Joyi Zachrel, Adira Shah, Hemin P Small, Elizabeth Watts, Charlie T Croonquist, Paula Devergne, Olivier Jones, Amy K Taylor, Elizabeth E Kagey, Jacob D Merkle, Julie A |
| author_facet | Nowaskie, Reagan R Kitch, Ashley Adams, Abby Anandaraj, Abinaya Apawan, Ethan Bañuelos, Liliana Betz, Cassandra J Bogunia, Julia M Buechlein, Nicholas Burns, Morgan R Collier, Hayley A Collins, Zach Combs, Kynzie Dakarian, Vana D Daniel, Abigail De Jesus III, Conrad M Erickson, John D Estrada, Bianca Estrada, Kevin Fields, Sydney Gabriel, Maya Garcia, Rosario M Gitamo, Sylvia Granath, Emma Hardin, Sabrina N Hattling, Emily Henriquez, Alexandra VL Hernandez, Destiny Johnson, Luke Kim, Annie H Kolley, Lillian K Larue, Katelynn M Lockwood, Erin Longoria, Nelia Lopez, Cassandra Lopez-Roca Fernandez, Rosario C Lozano, Sofia Manthie, Carissa May, Trinity Mehrzad, Zorah Mendoza, Itzel Mohan, Somya Mounthachak, Claylan Muyizere, Merveille Myers, Margaret R Newton, Jayce Nwawueze, Amarachi Paredes, Ariana J Pezdek, Marissa N Phat Nguyen, Hoang Pobuda, Nadia Sadat, Sahar Sailor, Johnathon J Santiago, David Sbarbaro, Madison Schultz III, David E Senobari, Anahita N Shouse, Emma M Snarski, Sarah M Solano, Estefanie Solis Campos, Naomi Stewart, Elnora Szczepaniak, Jessica Tejeda, Michael Teoli, Dominic F Tran, Michael Trivedi, Nishita Uribe Aristizabal, Laurita Vargas, Bryan Z Walker III, Kenneth W Wasiqi, Joseph Wong, Joyi Zachrel, Adira Shah, Hemin P Small, Elizabeth Watts, Charlie T Croonquist, Paula Devergne, Olivier Jones, Amy K Taylor, Elizabeth E Kagey, Jacob D Merkle, Julie A |
| author_sort | Nowaskie, Reagan R |
| collection | PubMed |
| description | Mutant B.4.1 , generated via EMS mutagenesis in Drosophila melanogaster , was studied by undergraduate students participating in the Fly-CURE. After inducing genetically mosaic tissue in the adult eye, B.4.1 mutant tissue displays a robust increase in cell division and a rough appearance. Complementation mapping and sequence analysis identified a nonsense mutation in the gene CG1603 , which we named clifford ( cliff ) due to observed increases in red-pigmented mutant tissue compared to controls. cliff encodes a zinc finger-containing protein implicated in transcriptional control. RNAi knockdown of cliff similarly results in rough eyes, confirming a role for Cliff in eye development. |
| format | Online Article Text |
| id | pubmed-10481159 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Caltech Library |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104811592023-09-07 clifford (B.4.1) , an allele of CG1603 , causes tissue overgrowth in the Drosophila melanogaster eye Nowaskie, Reagan R Kitch, Ashley Adams, Abby Anandaraj, Abinaya Apawan, Ethan Bañuelos, Liliana Betz, Cassandra J Bogunia, Julia M Buechlein, Nicholas Burns, Morgan R Collier, Hayley A Collins, Zach Combs, Kynzie Dakarian, Vana D Daniel, Abigail De Jesus III, Conrad M Erickson, John D Estrada, Bianca Estrada, Kevin Fields, Sydney Gabriel, Maya Garcia, Rosario M Gitamo, Sylvia Granath, Emma Hardin, Sabrina N Hattling, Emily Henriquez, Alexandra VL Hernandez, Destiny Johnson, Luke Kim, Annie H Kolley, Lillian K Larue, Katelynn M Lockwood, Erin Longoria, Nelia Lopez, Cassandra Lopez-Roca Fernandez, Rosario C Lozano, Sofia Manthie, Carissa May, Trinity Mehrzad, Zorah Mendoza, Itzel Mohan, Somya Mounthachak, Claylan Muyizere, Merveille Myers, Margaret R Newton, Jayce Nwawueze, Amarachi Paredes, Ariana J Pezdek, Marissa N Phat Nguyen, Hoang Pobuda, Nadia Sadat, Sahar Sailor, Johnathon J Santiago, David Sbarbaro, Madison Schultz III, David E Senobari, Anahita N Shouse, Emma M Snarski, Sarah M Solano, Estefanie Solis Campos, Naomi Stewart, Elnora Szczepaniak, Jessica Tejeda, Michael Teoli, Dominic F Tran, Michael Trivedi, Nishita Uribe Aristizabal, Laurita Vargas, Bryan Z Walker III, Kenneth W Wasiqi, Joseph Wong, Joyi Zachrel, Adira Shah, Hemin P Small, Elizabeth Watts, Charlie T Croonquist, Paula Devergne, Olivier Jones, Amy K Taylor, Elizabeth E Kagey, Jacob D Merkle, Julie A MicroPubl Biol New Finding Mutant B.4.1 , generated via EMS mutagenesis in Drosophila melanogaster , was studied by undergraduate students participating in the Fly-CURE. After inducing genetically mosaic tissue in the adult eye, B.4.1 mutant tissue displays a robust increase in cell division and a rough appearance. Complementation mapping and sequence analysis identified a nonsense mutation in the gene CG1603 , which we named clifford ( cliff ) due to observed increases in red-pigmented mutant tissue compared to controls. cliff encodes a zinc finger-containing protein implicated in transcriptional control. RNAi knockdown of cliff similarly results in rough eyes, confirming a role for Cliff in eye development. Caltech Library 2023-08-22 /pmc/articles/PMC10481159/ /pubmed/37680216 http://dx.doi.org/10.17912/micropub.biology.000936 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| spellingShingle | New Finding Nowaskie, Reagan R Kitch, Ashley Adams, Abby Anandaraj, Abinaya Apawan, Ethan Bañuelos, Liliana Betz, Cassandra J Bogunia, Julia M Buechlein, Nicholas Burns, Morgan R Collier, Hayley A Collins, Zach Combs, Kynzie Dakarian, Vana D Daniel, Abigail De Jesus III, Conrad M Erickson, John D Estrada, Bianca Estrada, Kevin Fields, Sydney Gabriel, Maya Garcia, Rosario M Gitamo, Sylvia Granath, Emma Hardin, Sabrina N Hattling, Emily Henriquez, Alexandra VL Hernandez, Destiny Johnson, Luke Kim, Annie H Kolley, Lillian K Larue, Katelynn M Lockwood, Erin Longoria, Nelia Lopez, Cassandra Lopez-Roca Fernandez, Rosario C Lozano, Sofia Manthie, Carissa May, Trinity Mehrzad, Zorah Mendoza, Itzel Mohan, Somya Mounthachak, Claylan Muyizere, Merveille Myers, Margaret R Newton, Jayce Nwawueze, Amarachi Paredes, Ariana J Pezdek, Marissa N Phat Nguyen, Hoang Pobuda, Nadia Sadat, Sahar Sailor, Johnathon J Santiago, David Sbarbaro, Madison Schultz III, David E Senobari, Anahita N Shouse, Emma M Snarski, Sarah M Solano, Estefanie Solis Campos, Naomi Stewart, Elnora Szczepaniak, Jessica Tejeda, Michael Teoli, Dominic F Tran, Michael Trivedi, Nishita Uribe Aristizabal, Laurita Vargas, Bryan Z Walker III, Kenneth W Wasiqi, Joseph Wong, Joyi Zachrel, Adira Shah, Hemin P Small, Elizabeth Watts, Charlie T Croonquist, Paula Devergne, Olivier Jones, Amy K Taylor, Elizabeth E Kagey, Jacob D Merkle, Julie A clifford (B.4.1) , an allele of CG1603 , causes tissue overgrowth in the Drosophila melanogaster eye |
| title |
clifford
(B.4.1)
, an allele of
CG1603
, causes tissue overgrowth in the
Drosophila melanogaster
eye
|
| title_full |
clifford
(B.4.1)
, an allele of
CG1603
, causes tissue overgrowth in the
Drosophila melanogaster
eye
|
| title_fullStr |
clifford
(B.4.1)
, an allele of
CG1603
, causes tissue overgrowth in the
Drosophila melanogaster
eye
|
| title_full_unstemmed |
clifford
(B.4.1)
, an allele of
CG1603
, causes tissue overgrowth in the
Drosophila melanogaster
eye
|
| title_short |
clifford
(B.4.1)
, an allele of
CG1603
, causes tissue overgrowth in the
Drosophila melanogaster
eye
|
| title_sort | clifford
(b.4.1)
, an allele of
cg1603
, causes tissue overgrowth in the
drosophila melanogaster
eye |
| topic | New Finding |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481159/ https://www.ncbi.nlm.nih.gov/pubmed/37680216 http://dx.doi.org/10.17912/micropub.biology.000936 |
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