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Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration
Type H vessels couple angiogenesis with osteogenesis, while sympathetic cues regulate vascular and skeletal function. The crosstalk between sympathetic nerves and type H vessels in bone remains unclear. Here, we first identify close spatial connections between sympathetic nerves and type H vessels i...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481296/ https://www.ncbi.nlm.nih.gov/pubmed/37680481 http://dx.doi.org/10.1016/j.isci.2023.107455 |
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author | Xu, Hao-Kun Liu, Jie-Xi Zheng, Chen-Xi Liu, Lu Ma, Chao Tian, Jiong-Yi Yuan, Yuan Cao, Yuan Xing, Shu-Juan Liu, Si-Ying Li, Qiang Zhao, Ya-Juan Kong, Liang Chen, Yong-Jin Sui, Bing-Dong |
author_facet | Xu, Hao-Kun Liu, Jie-Xi Zheng, Chen-Xi Liu, Lu Ma, Chao Tian, Jiong-Yi Yuan, Yuan Cao, Yuan Xing, Shu-Juan Liu, Si-Ying Li, Qiang Zhao, Ya-Juan Kong, Liang Chen, Yong-Jin Sui, Bing-Dong |
author_sort | Xu, Hao-Kun |
collection | PubMed |
description | Type H vessels couple angiogenesis with osteogenesis, while sympathetic cues regulate vascular and skeletal function. The crosstalk between sympathetic nerves and type H vessels in bone remains unclear. Here, we first identify close spatial connections between sympathetic nerves and type H vessels in bone, particularly in metaphysis. Sympathoexcitation, mimicked by isoproterenol (ISO) injection, reduces type H vessels and bone mass. Conversely, beta-2-adrenergic receptor (ADRB2) deficiency maintains type H vessels and bone mass in the physiological condition. In vitro experiments reveal indirect sympathetic modulation of angiogenesis via paracrine effects of mesenchymal stem cells (MSCs), which alter the transcription of multiple angiogenic genes in endothelial cells (ECs). Furthermore, Notch signaling in ECs underlies sympathoexcitation-regulated type H vessel formation, impacting osteogenesis and bone mass. Finally, propranolol (PRO) inhibits beta-adrenergic activity and protects type H vessels and bone mass against estrogen deficiency. These findings unravel the specialized neurovascular coupling in bone homeostasis and regeneration. |
format | Online Article Text |
id | pubmed-10481296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104812962023-09-07 Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration Xu, Hao-Kun Liu, Jie-Xi Zheng, Chen-Xi Liu, Lu Ma, Chao Tian, Jiong-Yi Yuan, Yuan Cao, Yuan Xing, Shu-Juan Liu, Si-Ying Li, Qiang Zhao, Ya-Juan Kong, Liang Chen, Yong-Jin Sui, Bing-Dong iScience Article Type H vessels couple angiogenesis with osteogenesis, while sympathetic cues regulate vascular and skeletal function. The crosstalk between sympathetic nerves and type H vessels in bone remains unclear. Here, we first identify close spatial connections between sympathetic nerves and type H vessels in bone, particularly in metaphysis. Sympathoexcitation, mimicked by isoproterenol (ISO) injection, reduces type H vessels and bone mass. Conversely, beta-2-adrenergic receptor (ADRB2) deficiency maintains type H vessels and bone mass in the physiological condition. In vitro experiments reveal indirect sympathetic modulation of angiogenesis via paracrine effects of mesenchymal stem cells (MSCs), which alter the transcription of multiple angiogenic genes in endothelial cells (ECs). Furthermore, Notch signaling in ECs underlies sympathoexcitation-regulated type H vessel formation, impacting osteogenesis and bone mass. Finally, propranolol (PRO) inhibits beta-adrenergic activity and protects type H vessels and bone mass against estrogen deficiency. These findings unravel the specialized neurovascular coupling in bone homeostasis and regeneration. Elsevier 2023-07-22 /pmc/articles/PMC10481296/ /pubmed/37680481 http://dx.doi.org/10.1016/j.isci.2023.107455 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Xu, Hao-Kun Liu, Jie-Xi Zheng, Chen-Xi Liu, Lu Ma, Chao Tian, Jiong-Yi Yuan, Yuan Cao, Yuan Xing, Shu-Juan Liu, Si-Ying Li, Qiang Zhao, Ya-Juan Kong, Liang Chen, Yong-Jin Sui, Bing-Dong Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration |
title | Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration |
title_full | Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration |
title_fullStr | Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration |
title_full_unstemmed | Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration |
title_short | Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration |
title_sort | region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481296/ https://www.ncbi.nlm.nih.gov/pubmed/37680481 http://dx.doi.org/10.1016/j.isci.2023.107455 |
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