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Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation
The Thrombotic Microangiopathy Banff Working Group (TMA-BWG) was formed in 2015 to survey current practices and develop minimum diagnostic criteria (MDC) for renal transplant TMA (Tx-TMA). To generate consensus among pathologists and nephrologists, the TMA BWG designed a 3-Phase study. Phase I of th...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481336/ https://www.ncbi.nlm.nih.gov/pubmed/37680647 http://dx.doi.org/10.3389/ti.2023.11589 |
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author | Afrouzian, Marjan Kozakowski, Nicolas Liapis, Helen Broecker, Verena Truong, Luan Avila-Casado, Carmen Regele, Heinz Seshan, Surya Ambruzs, Josephine M. Farris, Alton Brad Buob, David Chander, Praveen N. Cheraghvandi, Lukman Clahsen-van Groningen, Marian C. de Almeida Araujo, Stanley Ertoy Baydar, Dilek Formby, Mark Galesic Ljubanovic, Danica Herrera Hernandez, Loren Honsova, Eva Mohamed, Nasreen Ozluk, Yasemin Rabant, Marion Royal, Virginie Stevenson, Heather L. Toniolo, Maria Fernanda Taheri, Diana |
author_facet | Afrouzian, Marjan Kozakowski, Nicolas Liapis, Helen Broecker, Verena Truong, Luan Avila-Casado, Carmen Regele, Heinz Seshan, Surya Ambruzs, Josephine M. Farris, Alton Brad Buob, David Chander, Praveen N. Cheraghvandi, Lukman Clahsen-van Groningen, Marian C. de Almeida Araujo, Stanley Ertoy Baydar, Dilek Formby, Mark Galesic Ljubanovic, Danica Herrera Hernandez, Loren Honsova, Eva Mohamed, Nasreen Ozluk, Yasemin Rabant, Marion Royal, Virginie Stevenson, Heather L. Toniolo, Maria Fernanda Taheri, Diana |
author_sort | Afrouzian, Marjan |
collection | PubMed |
description | The Thrombotic Microangiopathy Banff Working Group (TMA-BWG) was formed in 2015 to survey current practices and develop minimum diagnostic criteria (MDC) for renal transplant TMA (Tx-TMA). To generate consensus among pathologists and nephrologists, the TMA BWG designed a 3-Phase study. Phase I of the study is presented here. Using the Delphi methodology, 23 panelists with >3 years of diagnostic experience with Tx-TMA pathology listed their MDC suggesting light, immunofluorescence, and electron microscopy lesions, clinical and laboratory information, and differential diagnoses. Nine rounds (R) of consensus resulted in MDC validated during two Rs using online evaluation of whole slide digital images of 37 biopsies (28 TMA, 9 non-TMA). Starting with 338 criteria the process resulted in 24 criteria and 8 differential diagnoses including 18 pathologic, 2 clinical, and 4 laboratory criteria. Results show that 3/4 of the panelists agreed on the diagnosis of 3/4 of cases. The process also allowed definition refinement for 4 light and 4 electron microscopy lesions. For the first time in Banff classification, the Delphi methodology was used to generate consensus. The study shows that Delphi is a democratic and cost-effective method allowing rapid consensus generation among numerous physicians dealing with large number of criteria in transplantation. |
format | Online Article Text |
id | pubmed-10481336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104813362023-09-07 Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation Afrouzian, Marjan Kozakowski, Nicolas Liapis, Helen Broecker, Verena Truong, Luan Avila-Casado, Carmen Regele, Heinz Seshan, Surya Ambruzs, Josephine M. Farris, Alton Brad Buob, David Chander, Praveen N. Cheraghvandi, Lukman Clahsen-van Groningen, Marian C. de Almeida Araujo, Stanley Ertoy Baydar, Dilek Formby, Mark Galesic Ljubanovic, Danica Herrera Hernandez, Loren Honsova, Eva Mohamed, Nasreen Ozluk, Yasemin Rabant, Marion Royal, Virginie Stevenson, Heather L. Toniolo, Maria Fernanda Taheri, Diana Transpl Int Health Archive The Thrombotic Microangiopathy Banff Working Group (TMA-BWG) was formed in 2015 to survey current practices and develop minimum diagnostic criteria (MDC) for renal transplant TMA (Tx-TMA). To generate consensus among pathologists and nephrologists, the TMA BWG designed a 3-Phase study. Phase I of the study is presented here. Using the Delphi methodology, 23 panelists with >3 years of diagnostic experience with Tx-TMA pathology listed their MDC suggesting light, immunofluorescence, and electron microscopy lesions, clinical and laboratory information, and differential diagnoses. Nine rounds (R) of consensus resulted in MDC validated during two Rs using online evaluation of whole slide digital images of 37 biopsies (28 TMA, 9 non-TMA). Starting with 338 criteria the process resulted in 24 criteria and 8 differential diagnoses including 18 pathologic, 2 clinical, and 4 laboratory criteria. Results show that 3/4 of the panelists agreed on the diagnosis of 3/4 of cases. The process also allowed definition refinement for 4 light and 4 electron microscopy lesions. For the first time in Banff classification, the Delphi methodology was used to generate consensus. The study shows that Delphi is a democratic and cost-effective method allowing rapid consensus generation among numerous physicians dealing with large number of criteria in transplantation. Frontiers Media S.A. 2023-08-23 /pmc/articles/PMC10481336/ /pubmed/37680647 http://dx.doi.org/10.3389/ti.2023.11589 Text en Copyright © 2023 Afrouzian, Kozakowski, Liapis, Broecker, Truong, Avila-Casado, Regele, Seshan, Ambruzs, Farris, Buob, Chander, Cheraghvandi, Clahsen-van Groningen, de Almeida Araujo, Ertoy Baydar, Formby, Galesic Ljubanovic, Herrera Hernandez, Honsova, Mohamed, Ozluk, Rabant, Royal, Stevenson, Toniolo and Taheri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Afrouzian, Marjan Kozakowski, Nicolas Liapis, Helen Broecker, Verena Truong, Luan Avila-Casado, Carmen Regele, Heinz Seshan, Surya Ambruzs, Josephine M. Farris, Alton Brad Buob, David Chander, Praveen N. Cheraghvandi, Lukman Clahsen-van Groningen, Marian C. de Almeida Araujo, Stanley Ertoy Baydar, Dilek Formby, Mark Galesic Ljubanovic, Danica Herrera Hernandez, Loren Honsova, Eva Mohamed, Nasreen Ozluk, Yasemin Rabant, Marion Royal, Virginie Stevenson, Heather L. Toniolo, Maria Fernanda Taheri, Diana Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation |
title | Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation |
title_full | Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation |
title_fullStr | Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation |
title_full_unstemmed | Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation |
title_short | Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation |
title_sort | delphi: a democratic and cost-effective method of consensus generation in transplantation |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481336/ https://www.ncbi.nlm.nih.gov/pubmed/37680647 http://dx.doi.org/10.3389/ti.2023.11589 |
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