Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy

Non-natural nucleobase isocytosine (IC) is the isomer of cytosine; its chemical derivate 5-fluoroisocytosine (5-FIC) together with the isocytosine-specific deaminase (ICD) VCZ was suggested to be potential practical enzyme/prodrug pair for cancer therapy through gene-directed enzyme-prodrug therapy...

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Detalles Bibliográficos
Autores principales: Guo, Wenting, Li, Xiaojia, Fan, Jingyu, Li, Hongwei, Wen, Yan, Meng, Chunyan, Chen, Haitao, Zhao, Zhipeng, Zhang, Yuling, Du, Yushen, Wu, Baixing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481359/
https://www.ncbi.nlm.nih.gov/pubmed/37680460
http://dx.doi.org/10.1016/j.isci.2023.107672

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