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Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements

Introduction Anabolic androgenic steroids (AAS) and diet supplements (DS) are frequently used by bodybuilders. In this specific group, increased muscle mass, the acute effects of exercise, and the use of creatine may affect the creatinine-based estimated glomerular filtration rate (eGFRcr), potentia...

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Autores principales: Ozkurt, Sultan, Ozakin, Engin, Gungor, Hilal, Yalcin, Ahmet Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481367/
https://www.ncbi.nlm.nih.gov/pubmed/37680426
http://dx.doi.org/10.7759/cureus.43058
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author Ozkurt, Sultan
Ozakin, Engin
Gungor, Hilal
Yalcin, Ahmet Ugur
author_facet Ozkurt, Sultan
Ozakin, Engin
Gungor, Hilal
Yalcin, Ahmet Ugur
author_sort Ozkurt, Sultan
collection PubMed
description Introduction Anabolic androgenic steroids (AAS) and diet supplements (DS) are frequently used by bodybuilders. In this specific group, increased muscle mass, the acute effects of exercise, and the use of creatine may affect the creatinine-based estimated glomerular filtration rate (eGFRcr), potentially leading to an underestimation of the GFR. Cystatin C equations offer a more accurate prediction of GFR that is independent of muscle mass. We aimed to assess the renal functions of bodybuilders who use both AAS+DS, as well as those who only use DS, by calculating the GFR based on cystatin C (eGFRcys) and also using a combination of cystatin C and creatinine (eGFRcys/cr). Methods The study included 12 bodybuilders using AAS+DS and 12 bodybuilders using DS. In both groups, serum cystatin C levels, eGFRcys, eGFRcys/cr, urine albumin excretion rates, urine protein excretion rates, and routine tests were examined. Results In AAS+DS users, the average duration of AAS use was 3.08±2.02 years, while for DS users, the duration of supplement use was 3.67±2.49 years. The spot urine albumin/creatinine and protein/creatinine ratios were higher in AAS+DS users (p<0.001 and p=0.006, respectively). Although eGFRcr was found to be similar in the AAS+DS and DS groups (119.67 ± 24.12 ml/min and 122.08 ± 18.03 ml/min, respectively; p=0.426), eGFRcys and the eGFRcys/cr ratio were significantly lower in the AAS+DS group compared to the DS group (eGFRcys: 120.67 ± 19.48 ml/min vs. 122.08 ± 18.03 ml/min, p=0.039; eGFRcys/cr: 121.83 ± 20.62 ml/min vs. 126.33 ± 21.163 ml/min, p= 0.036, respectively). Conclusion Cystatin-based GFR values were found to be significantly lower in AAS+DS users, and urinary albumin and protein excretion were considerably higher compared to DS users. Although these findings suggest a potential link between early kidney damage and the direct use of AAS, the topic requires further investigation.
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spelling pubmed-104813672023-09-07 Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements Ozkurt, Sultan Ozakin, Engin Gungor, Hilal Yalcin, Ahmet Ugur Cureus Nephrology Introduction Anabolic androgenic steroids (AAS) and diet supplements (DS) are frequently used by bodybuilders. In this specific group, increased muscle mass, the acute effects of exercise, and the use of creatine may affect the creatinine-based estimated glomerular filtration rate (eGFRcr), potentially leading to an underestimation of the GFR. Cystatin C equations offer a more accurate prediction of GFR that is independent of muscle mass. We aimed to assess the renal functions of bodybuilders who use both AAS+DS, as well as those who only use DS, by calculating the GFR based on cystatin C (eGFRcys) and also using a combination of cystatin C and creatinine (eGFRcys/cr). Methods The study included 12 bodybuilders using AAS+DS and 12 bodybuilders using DS. In both groups, serum cystatin C levels, eGFRcys, eGFRcys/cr, urine albumin excretion rates, urine protein excretion rates, and routine tests were examined. Results In AAS+DS users, the average duration of AAS use was 3.08±2.02 years, while for DS users, the duration of supplement use was 3.67±2.49 years. The spot urine albumin/creatinine and protein/creatinine ratios were higher in AAS+DS users (p<0.001 and p=0.006, respectively). Although eGFRcr was found to be similar in the AAS+DS and DS groups (119.67 ± 24.12 ml/min and 122.08 ± 18.03 ml/min, respectively; p=0.426), eGFRcys and the eGFRcys/cr ratio were significantly lower in the AAS+DS group compared to the DS group (eGFRcys: 120.67 ± 19.48 ml/min vs. 122.08 ± 18.03 ml/min, p=0.039; eGFRcys/cr: 121.83 ± 20.62 ml/min vs. 126.33 ± 21.163 ml/min, p= 0.036, respectively). Conclusion Cystatin-based GFR values were found to be significantly lower in AAS+DS users, and urinary albumin and protein excretion were considerably higher compared to DS users. Although these findings suggest a potential link between early kidney damage and the direct use of AAS, the topic requires further investigation. Cureus 2023-08-07 /pmc/articles/PMC10481367/ /pubmed/37680426 http://dx.doi.org/10.7759/cureus.43058 Text en Copyright © 2023, Ozkurt et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Nephrology
Ozkurt, Sultan
Ozakin, Engin
Gungor, Hilal
Yalcin, Ahmet Ugur
Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements
title Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements
title_full Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements
title_fullStr Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements
title_full_unstemmed Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements
title_short Assessment of Renal Function of Bodybuilders Using Anabolic Androgenic Steroids and Diet Supplements
title_sort assessment of renal function of bodybuilders using anabolic androgenic steroids and diet supplements
topic Nephrology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481367/
https://www.ncbi.nlm.nih.gov/pubmed/37680426
http://dx.doi.org/10.7759/cureus.43058
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