Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review

Curcumin has anti-inflammatory, antioxidant, and anticancer effects and is used to treat diseases such as dermatological diseases, infection, stress, depression, and anxiety. J147, an analogue of curcumin, is designed and synthesized with better stability and bioavailability. Accumulating evidence d...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Fang, Wang, Yanmei, Du, Yunbo, Zeng, Changchun, Liu, Yuqiang, Pan, Haobo, Ke, Changneng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481599/
https://www.ncbi.nlm.nih.gov/pubmed/37674139
http://dx.doi.org/10.1186/s12883-023-03358-5
_version_ 1785102013599580160
author Qiu, Fang
Wang, Yanmei
Du, Yunbo
Zeng, Changchun
Liu, Yuqiang
Pan, Haobo
Ke, Changneng
author_facet Qiu, Fang
Wang, Yanmei
Du, Yunbo
Zeng, Changchun
Liu, Yuqiang
Pan, Haobo
Ke, Changneng
author_sort Qiu, Fang
collection PubMed
description Curcumin has anti-inflammatory, antioxidant, and anticancer effects and is used to treat diseases such as dermatological diseases, infection, stress, depression, and anxiety. J147, an analogue of curcumin, is designed and synthesized with better stability and bioavailability. Accumulating evidence demonstrates the potential role of J147 in the prevention and treatment of Alzheimer’s disease, diabetic neuropathy, ischemic stroke, depression, anxiety, and fatty liver disease. In this narrative review, we summarized the background and biochemical properties of J147 and discussed the role and mechanism of J147 in different diseases. Overall, the mechanical attributes of J147 connote it as a potential target for the prevention and treatment of neurological diseases.
format Online
Article
Text
id pubmed-10481599
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-104815992023-09-07 Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review Qiu, Fang Wang, Yanmei Du, Yunbo Zeng, Changchun Liu, Yuqiang Pan, Haobo Ke, Changneng BMC Neurol Review Curcumin has anti-inflammatory, antioxidant, and anticancer effects and is used to treat diseases such as dermatological diseases, infection, stress, depression, and anxiety. J147, an analogue of curcumin, is designed and synthesized with better stability and bioavailability. Accumulating evidence demonstrates the potential role of J147 in the prevention and treatment of Alzheimer’s disease, diabetic neuropathy, ischemic stroke, depression, anxiety, and fatty liver disease. In this narrative review, we summarized the background and biochemical properties of J147 and discussed the role and mechanism of J147 in different diseases. Overall, the mechanical attributes of J147 connote it as a potential target for the prevention and treatment of neurological diseases. BioMed Central 2023-09-06 /pmc/articles/PMC10481599/ /pubmed/37674139 http://dx.doi.org/10.1186/s12883-023-03358-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Qiu, Fang
Wang, Yanmei
Du, Yunbo
Zeng, Changchun
Liu, Yuqiang
Pan, Haobo
Ke, Changneng
Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
title Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
title_full Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
title_fullStr Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
title_full_unstemmed Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
title_short Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
title_sort current evidence for j147 as a potential therapeutic agent in nervous system disease: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481599/
https://www.ncbi.nlm.nih.gov/pubmed/37674139
http://dx.doi.org/10.1186/s12883-023-03358-5
work_keys_str_mv AT qiufang currentevidenceforj147asapotentialtherapeuticagentinnervoussystemdiseaseanarrativereview
AT wangyanmei currentevidenceforj147asapotentialtherapeuticagentinnervoussystemdiseaseanarrativereview
AT duyunbo currentevidenceforj147asapotentialtherapeuticagentinnervoussystemdiseaseanarrativereview
AT zengchangchun currentevidenceforj147asapotentialtherapeuticagentinnervoussystemdiseaseanarrativereview
AT liuyuqiang currentevidenceforj147asapotentialtherapeuticagentinnervoussystemdiseaseanarrativereview
AT panhaobo currentevidenceforj147asapotentialtherapeuticagentinnervoussystemdiseaseanarrativereview
AT kechangneng currentevidenceforj147asapotentialtherapeuticagentinnervoussystemdiseaseanarrativereview

Ejemplares similares