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Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease

OBJECTIVES: This study aimed to investigate the risk factors of lung progression in patients with connective tissue disease-associated interstitial lung disease (ILD). PATIENTS AND METHODS: A total of 91 ILD patients (28 males, 63 females; mean age: 54.9±11.3 years; range, 30 to 77 years) were inclu...

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Autores principales: Zhao, Ting, Lin, Fu-an, Chen, Hongpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish League Against Rheumatism 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481697/
https://www.ncbi.nlm.nih.gov/pubmed/37680526
http://dx.doi.org/10.46497/ArchRheumatol.2023.9602
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author Zhao, Ting
Lin, Fu-an
Chen, Hongpu
author_facet Zhao, Ting
Lin, Fu-an
Chen, Hongpu
author_sort Zhao, Ting
collection PubMed
description OBJECTIVES: This study aimed to investigate the risk factors of lung progression in patients with connective tissue disease-associated interstitial lung disease (ILD). PATIENTS AND METHODS: A total of 91 ILD patients (28 males, 63 females; mean age: 54.9±11.3 years; range, 30 to 77 years) were included in the prospective follow-up study conducted throughout 2020. They were divided into progressors (n=27) and nonprogressors (n=64) according to whether the pulmonary disease progressed during a six-month follow-up period. The clinical data of the two groups were analyzed, and a logistic regression model was constructed to analyze the risk factors of the progression of ILD in all patients. RESULTS: Univariate analysis revealed significant differences (p<0.05) between the two groups in smoking history, serum ferritin, FVC% (the percentage of forced vital capacity), DLCO% (the percentage of diffusion capacity for carbon monoxide), and computed tomography involvement range. Further application of a logistic regression model revealed that increased serum ferritin level was an independent risk factor for ILD progression (odds ratio=1.002, 95% confidence interval: 1.000-1.003, p=0.004). The optimal critical value of serum ferritin was 303.25 ng/mL, the sensitivity and specificity were 81.5% and 54.7%, respectively, and the area under the curve was 0.747. CONCLUSION: The level of serum ferritin may be an independent predictor for ILD progression.
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spelling pubmed-104816972023-09-07 Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease Zhao, Ting Lin, Fu-an Chen, Hongpu Arch Rheumatol Original Article OBJECTIVES: This study aimed to investigate the risk factors of lung progression in patients with connective tissue disease-associated interstitial lung disease (ILD). PATIENTS AND METHODS: A total of 91 ILD patients (28 males, 63 females; mean age: 54.9±11.3 years; range, 30 to 77 years) were included in the prospective follow-up study conducted throughout 2020. They were divided into progressors (n=27) and nonprogressors (n=64) according to whether the pulmonary disease progressed during a six-month follow-up period. The clinical data of the two groups were analyzed, and a logistic regression model was constructed to analyze the risk factors of the progression of ILD in all patients. RESULTS: Univariate analysis revealed significant differences (p<0.05) between the two groups in smoking history, serum ferritin, FVC% (the percentage of forced vital capacity), DLCO% (the percentage of diffusion capacity for carbon monoxide), and computed tomography involvement range. Further application of a logistic regression model revealed that increased serum ferritin level was an independent risk factor for ILD progression (odds ratio=1.002, 95% confidence interval: 1.000-1.003, p=0.004). The optimal critical value of serum ferritin was 303.25 ng/mL, the sensitivity and specificity were 81.5% and 54.7%, respectively, and the area under the curve was 0.747. CONCLUSION: The level of serum ferritin may be an independent predictor for ILD progression. Turkish League Against Rheumatism 2022-11-04 /pmc/articles/PMC10481697/ /pubmed/37680526 http://dx.doi.org/10.46497/ArchRheumatol.2023.9602 Text en Copyright © 2023, Turkish League Against Rheumatism https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Article
Zhao, Ting
Lin, Fu-an
Chen, Hongpu
Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease
title Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease
title_full Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease
title_fullStr Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease
title_full_unstemmed Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease
title_short Analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease
title_sort analysis of risk factors for the progression and prognosis of connective tissue disease-associated interstitial lung disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481697/
https://www.ncbi.nlm.nih.gov/pubmed/37680526
http://dx.doi.org/10.46497/ArchRheumatol.2023.9602
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