The ABCs of antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-β2 glycoprotein-I antibody (aβ2GPI), and lupus...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Turkish League Against Rheumatism
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481699/ https://www.ncbi.nlm.nih.gov/pubmed/37680521 http://dx.doi.org/10.46497/ArchRheumatol.2023.41875 |
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author | Bahar Keleşoğlu Dinçer, Ayşe Erkan, Doruk |
author_facet | Bahar Keleşoğlu Dinçer, Ayşe Erkan, Doruk |
author_sort | Bahar Keleşoğlu Dinçer, Ayşe |
collection | PubMed |
description | Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-β2 glycoprotein-I antibody (aβ2GPI), and lupus anticoagulant (LA). The diagnosis of APS requires careful assessment of the aPL profile, the clinical phenotype, and additional risk factors. The standard management of aPL-related thrombosis is anticoagulation, which is not effective for microvascular and non-thrombotic events. In parallel to our improved understanding of aPL-related mechanisms, the role of immunosuppression has been increasingly investigated. In this review, we summarize the basic concepts and future perspectives in APS. |
format | Online Article Text |
id | pubmed-10481699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Turkish League Against Rheumatism |
record_format | MEDLINE/PubMed |
spelling | pubmed-104816992023-09-07 The ABCs of antiphospholipid syndrome Bahar Keleşoğlu Dinçer, Ayşe Erkan, Doruk Arch Rheumatol Review Article Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-β2 glycoprotein-I antibody (aβ2GPI), and lupus anticoagulant (LA). The diagnosis of APS requires careful assessment of the aPL profile, the clinical phenotype, and additional risk factors. The standard management of aPL-related thrombosis is anticoagulation, which is not effective for microvascular and non-thrombotic events. In parallel to our improved understanding of aPL-related mechanisms, the role of immunosuppression has been increasingly investigated. In this review, we summarize the basic concepts and future perspectives in APS. Turkish League Against Rheumatism 2023-06-05 /pmc/articles/PMC10481699/ /pubmed/37680521 http://dx.doi.org/10.46497/ArchRheumatol.2023.41875 Text en Copyright © 2023, Turkish League Against Rheumatism https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Article Bahar Keleşoğlu Dinçer, Ayşe Erkan, Doruk The ABCs of antiphospholipid syndrome |
title | The ABCs of antiphospholipid syndrome |
title_full | The ABCs of antiphospholipid syndrome |
title_fullStr | The ABCs of antiphospholipid syndrome |
title_full_unstemmed | The ABCs of antiphospholipid syndrome |
title_short | The ABCs of antiphospholipid syndrome |
title_sort | abcs of antiphospholipid syndrome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481699/ https://www.ncbi.nlm.nih.gov/pubmed/37680521 http://dx.doi.org/10.46497/ArchRheumatol.2023.41875 |
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