The ABCs of antiphospholipid syndrome

Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-β2 glycoprotein-I antibody (aβ2GPI), and lupus...

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Autores principales: Bahar Keleşoğlu Dinçer, Ayşe, Erkan, Doruk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish League Against Rheumatism 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481699/
https://www.ncbi.nlm.nih.gov/pubmed/37680521
http://dx.doi.org/10.46497/ArchRheumatol.2023.41875
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author Bahar Keleşoğlu Dinçer, Ayşe
Erkan, Doruk
author_facet Bahar Keleşoğlu Dinçer, Ayşe
Erkan, Doruk
author_sort Bahar Keleşoğlu Dinçer, Ayşe
collection PubMed
description Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-β2 glycoprotein-I antibody (aβ2GPI), and lupus anticoagulant (LA). The diagnosis of APS requires careful assessment of the aPL profile, the clinical phenotype, and additional risk factors. The standard management of aPL-related thrombosis is anticoagulation, which is not effective for microvascular and non-thrombotic events. In parallel to our improved understanding of aPL-related mechanisms, the role of immunosuppression has been increasingly investigated. In this review, we summarize the basic concepts and future perspectives in APS.
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spelling pubmed-104816992023-09-07 The ABCs of antiphospholipid syndrome Bahar Keleşoğlu Dinçer, Ayşe Erkan, Doruk Arch Rheumatol Review Article Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-β2 glycoprotein-I antibody (aβ2GPI), and lupus anticoagulant (LA). The diagnosis of APS requires careful assessment of the aPL profile, the clinical phenotype, and additional risk factors. The standard management of aPL-related thrombosis is anticoagulation, which is not effective for microvascular and non-thrombotic events. In parallel to our improved understanding of aPL-related mechanisms, the role of immunosuppression has been increasingly investigated. In this review, we summarize the basic concepts and future perspectives in APS. Turkish League Against Rheumatism 2023-06-05 /pmc/articles/PMC10481699/ /pubmed/37680521 http://dx.doi.org/10.46497/ArchRheumatol.2023.41875 Text en Copyright © 2023, Turkish League Against Rheumatism https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Article
Bahar Keleşoğlu Dinçer, Ayşe
Erkan, Doruk
The ABCs of antiphospholipid syndrome
title The ABCs of antiphospholipid syndrome
title_full The ABCs of antiphospholipid syndrome
title_fullStr The ABCs of antiphospholipid syndrome
title_full_unstemmed The ABCs of antiphospholipid syndrome
title_short The ABCs of antiphospholipid syndrome
title_sort abcs of antiphospholipid syndrome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481699/
https://www.ncbi.nlm.nih.gov/pubmed/37680521
http://dx.doi.org/10.46497/ArchRheumatol.2023.41875
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