Cargando…
Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population
BACKGROUND: Radiotherapy has increasingly assumed a central role in the multidisciplinary treatment of skull base lesions. Unfortunately, it is often burdened by relevant radio-induced damage to the pituitary function and the surrounding structures and systems. Patients who were treated with radioth...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientific Scholar
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481810/ https://www.ncbi.nlm.nih.gov/pubmed/37680918 http://dx.doi.org/10.25259/SNI_41_2023 |
_version_ | 1785102054701662208 |
---|---|
author | Zoia, Cesare Todeschini, Giada Lovati, Elisabetta Lucotti, Pietro Iannalfi, Alberto Bongetta, Daniele Di Sabatino, Antonio Riva, Giulia Cavallo, Iacopo Orlandi, Ester Spena, Giannantonio |
author_facet | Zoia, Cesare Todeschini, Giada Lovati, Elisabetta Lucotti, Pietro Iannalfi, Alberto Bongetta, Daniele Di Sabatino, Antonio Riva, Giulia Cavallo, Iacopo Orlandi, Ester Spena, Giannantonio |
author_sort | Zoia, Cesare |
collection | PubMed |
description | BACKGROUND: Radiotherapy has increasingly assumed a central role in the multidisciplinary treatment of skull base lesions. Unfortunately, it is often burdened by relevant radio-induced damage to the pituitary function and the surrounding structures and systems. Patients who were treated with radiotherapy around the sellar region especially have a high risk of developing radio-induced hypopituitarism. Particle therapy has the potential advantage of delivering a higher radiation dose to the target while potentially sparing the sellar region and pituitary function. The aim of this study is to evaluate the pituitary function in adult patients who have undergone hadron therapy for anterior skull base lesions involving or surrounding the pituitary gland. METHODS: This is a retrospective, observational, and noncontrolled study. We evaluated pituitary and peripheral hormone levels in all patients referring to National Center for Oncological Hadrontherapy, Pavia, Italy for anterior skull base tumors. Furthermore, we performed a magnetic resonance imaging for every follow-up to evaluate potential tumoral growth. RESULTS: We evaluated 32 patients with different tumoral lesions with a mean follow-up of 27.9 months. The mean hadron therapy (HT) dose was 60 ± 14 Gray, with a mean dose per fraction of 2.3 ± 2.1 Gray. Six patients were treated with carbon ions and 26 with protons. Pituitary hormone alteration of some kind was reported for six patients. No patient experienced unexpected severe adverse events related to particle therapy. CONCLUSION: Particle radiotherapy performed on anterior skull base lesions has proved to cause limited damage to pituitary function in the adult population. |
format | Online Article Text |
id | pubmed-10481810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-104818102023-09-07 Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population Zoia, Cesare Todeschini, Giada Lovati, Elisabetta Lucotti, Pietro Iannalfi, Alberto Bongetta, Daniele Di Sabatino, Antonio Riva, Giulia Cavallo, Iacopo Orlandi, Ester Spena, Giannantonio Surg Neurol Int Original Article BACKGROUND: Radiotherapy has increasingly assumed a central role in the multidisciplinary treatment of skull base lesions. Unfortunately, it is often burdened by relevant radio-induced damage to the pituitary function and the surrounding structures and systems. Patients who were treated with radiotherapy around the sellar region especially have a high risk of developing radio-induced hypopituitarism. Particle therapy has the potential advantage of delivering a higher radiation dose to the target while potentially sparing the sellar region and pituitary function. The aim of this study is to evaluate the pituitary function in adult patients who have undergone hadron therapy for anterior skull base lesions involving or surrounding the pituitary gland. METHODS: This is a retrospective, observational, and noncontrolled study. We evaluated pituitary and peripheral hormone levels in all patients referring to National Center for Oncological Hadrontherapy, Pavia, Italy for anterior skull base tumors. Furthermore, we performed a magnetic resonance imaging for every follow-up to evaluate potential tumoral growth. RESULTS: We evaluated 32 patients with different tumoral lesions with a mean follow-up of 27.9 months. The mean hadron therapy (HT) dose was 60 ± 14 Gray, with a mean dose per fraction of 2.3 ± 2.1 Gray. Six patients were treated with carbon ions and 26 with protons. Pituitary hormone alteration of some kind was reported for six patients. No patient experienced unexpected severe adverse events related to particle therapy. CONCLUSION: Particle radiotherapy performed on anterior skull base lesions has proved to cause limited damage to pituitary function in the adult population. Scientific Scholar 2023-08-18 /pmc/articles/PMC10481810/ /pubmed/37680918 http://dx.doi.org/10.25259/SNI_41_2023 Text en Copyright: © 2023 Surgical Neurology International https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Zoia, Cesare Todeschini, Giada Lovati, Elisabetta Lucotti, Pietro Iannalfi, Alberto Bongetta, Daniele Di Sabatino, Antonio Riva, Giulia Cavallo, Iacopo Orlandi, Ester Spena, Giannantonio Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population |
title | Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population |
title_full | Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population |
title_fullStr | Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population |
title_full_unstemmed | Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population |
title_short | Evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population |
title_sort | evaluation of endocrinological sequelae following particle therapy performed on anterior skull base lesions in the adult population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481810/ https://www.ncbi.nlm.nih.gov/pubmed/37680918 http://dx.doi.org/10.25259/SNI_41_2023 |
work_keys_str_mv | AT zoiacesare evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT todeschinigiada evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT lovatielisabetta evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT lucottipietro evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT iannalfialberto evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT bongettadaniele evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT disabatinoantonio evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT rivagiulia evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT cavalloiacopo evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT orlandiester evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation AT spenagiannantonio evaluationofendocrinologicalsequelaefollowingparticletherapyperformedonanteriorskullbaselesionsintheadultpopulation |