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Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon benign disorder characterized by the accumulation of activated histiocytes in affected tissues. While RDD typically involves lymph nodes, it may manifest as extranodal involvement. Breast invo...

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Autores principales: Nguyen, Troy, Gutema, Malem, Ye, Jiquing, Backenstoss, Martine Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481821/
https://www.ncbi.nlm.nih.gov/pubmed/37680249
http://dx.doi.org/10.25259/JCIS_40_2023
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author Nguyen, Troy
Gutema, Malem
Ye, Jiquing
Backenstoss, Martine Susan
author_facet Nguyen, Troy
Gutema, Malem
Ye, Jiquing
Backenstoss, Martine Susan
author_sort Nguyen, Troy
collection PubMed
description Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon benign disorder characterized by the accumulation of activated histiocytes in affected tissues. While RDD typically involves lymph nodes, it may manifest as extranodal involvement. Breast involvement is an exceedingly rare presentation of this condition with <100 reported cases worldwide. This report presents a case of RDD in a 58-year-old male patient who presented with a palpable breast mass. Mammography and ultrasound imaging studies raised concerns for malignancy, prompting a breast biopsy. Histopathological examination revealed S100-positive pale histiocytes exhibiting emperipolesis, consistent with RDD. The management of extranodal RDD is individualized, as no standardized guidelines are currently available. However, surgical excision is recommended for unicentric breast lesions, which was performed in our case, resulting in complete remission. The patient has remained disease-free under surveillance with computed tomography scans. Our case underscores the importance of considering RDD in the differential diagnoses of breast masses and highlights the utility of surgical excision as an effective treatment option, especially for unicentric breast lesions of RDD.
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spelling pubmed-104818212023-09-07 Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm Nguyen, Troy Gutema, Malem Ye, Jiquing Backenstoss, Martine Susan J Clin Imaging Sci Case Report Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon benign disorder characterized by the accumulation of activated histiocytes in affected tissues. While RDD typically involves lymph nodes, it may manifest as extranodal involvement. Breast involvement is an exceedingly rare presentation of this condition with <100 reported cases worldwide. This report presents a case of RDD in a 58-year-old male patient who presented with a palpable breast mass. Mammography and ultrasound imaging studies raised concerns for malignancy, prompting a breast biopsy. Histopathological examination revealed S100-positive pale histiocytes exhibiting emperipolesis, consistent with RDD. The management of extranodal RDD is individualized, as no standardized guidelines are currently available. However, surgical excision is recommended for unicentric breast lesions, which was performed in our case, resulting in complete remission. The patient has remained disease-free under surveillance with computed tomography scans. Our case underscores the importance of considering RDD in the differential diagnoses of breast masses and highlights the utility of surgical excision as an effective treatment option, especially for unicentric breast lesions of RDD. Scientific Scholar 2023-08-22 /pmc/articles/PMC10481821/ /pubmed/37680249 http://dx.doi.org/10.25259/JCIS_40_2023 Text en © 2023 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Nguyen, Troy
Gutema, Malem
Ye, Jiquing
Backenstoss, Martine Susan
Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm
title Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm
title_full Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm
title_fullStr Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm
title_full_unstemmed Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm
title_short Mammary Rosai-Dorfman disease: Rare benign mimic of breast malignant neoplasm
title_sort mammary rosai-dorfman disease: rare benign mimic of breast malignant neoplasm
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481821/
https://www.ncbi.nlm.nih.gov/pubmed/37680249
http://dx.doi.org/10.25259/JCIS_40_2023
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