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Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure

Progesterone hypersensitivity (PH) is a rare hypersensitivity reaction to either endogenous or exogenous progesterone. There are around 200 reported cases of progesterone hypersensitivity in the medical literature. We present the case of a 31-year-old female who presented with cyclical urticaria and...

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Autores principales: Dhaliwal, Gurnoor, Batra, Jaskaran, Ankireddypalli, Anvitha R, Gorle, Swathi, Kanugula, Ashok Kumar, Kaur, Jasleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481886/
https://www.ncbi.nlm.nih.gov/pubmed/37680259
http://dx.doi.org/10.7759/cureus.44776
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author Dhaliwal, Gurnoor
Batra, Jaskaran
Ankireddypalli, Anvitha R
Gorle, Swathi
Kanugula, Ashok Kumar
Kaur, Jasleen
author_facet Dhaliwal, Gurnoor
Batra, Jaskaran
Ankireddypalli, Anvitha R
Gorle, Swathi
Kanugula, Ashok Kumar
Kaur, Jasleen
author_sort Dhaliwal, Gurnoor
collection PubMed
description Progesterone hypersensitivity (PH) is a rare hypersensitivity reaction to either endogenous or exogenous progesterone. There are around 200 reported cases of progesterone hypersensitivity in the medical literature. We present the case of a 31-year-old female who presented with cyclical urticaria and angioedema after exogenous progesterone exposure. Her symptoms would begin a few days before her menstrual cycle began and resolve after menstruation. She only had partial recovery of her symptoms with antihistamines, steroids, montelukast, and omalizumab. She needed treatment with oral contraceptives and had a resolution of symptoms, but subsequently developed a recurrence again. Given the rarity of this condition, the diagnosis is often delayed. This diagnosis should be considered for women of reproductive age who present with cyclic hypersensitivity or allergic symptoms.
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spelling pubmed-104818862023-09-07 Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure Dhaliwal, Gurnoor Batra, Jaskaran Ankireddypalli, Anvitha R Gorle, Swathi Kanugula, Ashok Kumar Kaur, Jasleen Cureus Endocrinology/Diabetes/Metabolism Progesterone hypersensitivity (PH) is a rare hypersensitivity reaction to either endogenous or exogenous progesterone. There are around 200 reported cases of progesterone hypersensitivity in the medical literature. We present the case of a 31-year-old female who presented with cyclical urticaria and angioedema after exogenous progesterone exposure. Her symptoms would begin a few days before her menstrual cycle began and resolve after menstruation. She only had partial recovery of her symptoms with antihistamines, steroids, montelukast, and omalizumab. She needed treatment with oral contraceptives and had a resolution of symptoms, but subsequently developed a recurrence again. Given the rarity of this condition, the diagnosis is often delayed. This diagnosis should be considered for women of reproductive age who present with cyclic hypersensitivity or allergic symptoms. Cureus 2023-09-06 /pmc/articles/PMC10481886/ /pubmed/37680259 http://dx.doi.org/10.7759/cureus.44776 Text en Copyright © 2023, Dhaliwal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Dhaliwal, Gurnoor
Batra, Jaskaran
Ankireddypalli, Anvitha R
Gorle, Swathi
Kanugula, Ashok Kumar
Kaur, Jasleen
Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure
title Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure
title_full Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure
title_fullStr Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure
title_full_unstemmed Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure
title_short Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure
title_sort progesterone hypersensitivity induced by exogenous progesterone exposure
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481886/
https://www.ncbi.nlm.nih.gov/pubmed/37680259
http://dx.doi.org/10.7759/cureus.44776
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