Alpaca single B cell interrogation and heavy-chain-only antibody discovery on an optofluidic platform

In vivo VHH discovery approaches have been limited by the lack of methodologies for camelid B cell interrogation. Here, we report a novel application of the Beacon® optofluidic platform to the discovery of heavy-chain-only antibodies by screening alpaca B cells. Methods for alpaca B cell enrichment,...

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Detalles Bibliográficos
Autores principales: Shapiro, Mariya B, Boucher, Jacqueline, Brousseau, Anna, Dehkharghani, Amin, Gabriel, Justin, Kamat, Vishal, Patil, Ketan, Gao, Feng, Walker, Jennifer, Kelly, Ryan, Souders, Colby A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481890/
https://www.ncbi.nlm.nih.gov/pubmed/37680350
http://dx.doi.org/10.1093/abt/tbad018

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