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The lung-gut crosstalk in respiratory and inflammatory bowel disease

Both lung and gut belong to the common mucosal immune system (CMIS), with huge surface areas exposed to the external environment. They are the main defense organs against the invasion of pathogens and play a key role in innate and adaptive immunity. Recently, more and more evidence showed that stimu...

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Autores principales: Du, Baoxiang, Fu, Yan, Han, Yuxiu, Sun, Qihui, Xu, Jinke, Yang, Yong, Rong, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482113/
https://www.ncbi.nlm.nih.gov/pubmed/37680747
http://dx.doi.org/10.3389/fcimb.2023.1218565
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author Du, Baoxiang
Fu, Yan
Han, Yuxiu
Sun, Qihui
Xu, Jinke
Yang, Yong
Rong, Rong
author_facet Du, Baoxiang
Fu, Yan
Han, Yuxiu
Sun, Qihui
Xu, Jinke
Yang, Yong
Rong, Rong
author_sort Du, Baoxiang
collection PubMed
description Both lung and gut belong to the common mucosal immune system (CMIS), with huge surface areas exposed to the external environment. They are the main defense organs against the invasion of pathogens and play a key role in innate and adaptive immunity. Recently, more and more evidence showed that stimulation of one organ can affect the other, as exemplified by intestinal complications during respiratory disease and vice versa, which is called lung-gut crosstalk. Intestinal microbiota plays an important role in respiratory and intestinal diseases. It is known that intestinal microbial imbalance is related to inflammatory bowel disease (IBD), this imbalance could impact the integrity of the intestinal epithelial barrier and leads to the persistence of inflammation, however, gut microbial disturbances have also been observed in respiratory diseases such as asthma, allergy, chronic obstructive pulmonary disease (COPD), and respiratory infection. It is not fully clarified how these disorders happened. In this review, we summarized the latest examples and possible mechanisms of lung-gut crosstalk in respiratory disease and IBD and discussed the strategy of shaping intestinal flora to treat respiratory diseases.
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spelling pubmed-104821132023-09-07 The lung-gut crosstalk in respiratory and inflammatory bowel disease Du, Baoxiang Fu, Yan Han, Yuxiu Sun, Qihui Xu, Jinke Yang, Yong Rong, Rong Front Cell Infect Microbiol Cellular and Infection Microbiology Both lung and gut belong to the common mucosal immune system (CMIS), with huge surface areas exposed to the external environment. They are the main defense organs against the invasion of pathogens and play a key role in innate and adaptive immunity. Recently, more and more evidence showed that stimulation of one organ can affect the other, as exemplified by intestinal complications during respiratory disease and vice versa, which is called lung-gut crosstalk. Intestinal microbiota plays an important role in respiratory and intestinal diseases. It is known that intestinal microbial imbalance is related to inflammatory bowel disease (IBD), this imbalance could impact the integrity of the intestinal epithelial barrier and leads to the persistence of inflammation, however, gut microbial disturbances have also been observed in respiratory diseases such as asthma, allergy, chronic obstructive pulmonary disease (COPD), and respiratory infection. It is not fully clarified how these disorders happened. In this review, we summarized the latest examples and possible mechanisms of lung-gut crosstalk in respiratory disease and IBD and discussed the strategy of shaping intestinal flora to treat respiratory diseases. Frontiers Media S.A. 2023-08-23 /pmc/articles/PMC10482113/ /pubmed/37680747 http://dx.doi.org/10.3389/fcimb.2023.1218565 Text en Copyright © 2023 Du, Fu, Han, Sun, Xu, Yang and Rong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Du, Baoxiang
Fu, Yan
Han, Yuxiu
Sun, Qihui
Xu, Jinke
Yang, Yong
Rong, Rong
The lung-gut crosstalk in respiratory and inflammatory bowel disease
title The lung-gut crosstalk in respiratory and inflammatory bowel disease
title_full The lung-gut crosstalk in respiratory and inflammatory bowel disease
title_fullStr The lung-gut crosstalk in respiratory and inflammatory bowel disease
title_full_unstemmed The lung-gut crosstalk in respiratory and inflammatory bowel disease
title_short The lung-gut crosstalk in respiratory and inflammatory bowel disease
title_sort lung-gut crosstalk in respiratory and inflammatory bowel disease
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482113/
https://www.ncbi.nlm.nih.gov/pubmed/37680747
http://dx.doi.org/10.3389/fcimb.2023.1218565
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