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Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease

INTRODUCTION: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at th...

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Autores principales: Miranda, Sofia, Clara, Patrícia, Rua, Joana, Cimbron, Miriam, Salvador, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482128/
https://www.ncbi.nlm.nih.gov/pubmed/37680785
http://dx.doi.org/10.12890/2023_003977
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author Miranda, Sofia
Clara, Patrícia
Rua, Joana
Cimbron, Miriam
Salvador, Fernando
author_facet Miranda, Sofia
Clara, Patrícia
Rua, Joana
Cimbron, Miriam
Salvador, Fernando
author_sort Miranda, Sofia
collection PubMed
description INTRODUCTION: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at the D2 level compatible with coeliac sprue and HLA typing positive for both DQ-2 and DQ-8. METHODS: A gluten free diet was started and apixaban was suspended. RESULTS: No new complications were reported. DISCUSSION: Multiple mechanisms are believed to be behind the association between DVT and coeliac disease. However, to this date, no consensus exists regarding the ideal duration of anticoagulation. LEARNING POINTS: Coeliac disease should always be considered a systemic disease. Thromboembolism is a possible extraintestinal manifestation of coeliac disease. Coeliac disease should be considered as a possible cause of thromboembolism even in the absence of gastrointestinal symptoms, which it can precede by several years.
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spelling pubmed-104821282023-09-07 Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease Miranda, Sofia Clara, Patrícia Rua, Joana Cimbron, Miriam Salvador, Fernando Eur J Case Rep Intern Med Article INTRODUCTION: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at the D2 level compatible with coeliac sprue and HLA typing positive for both DQ-2 and DQ-8. METHODS: A gluten free diet was started and apixaban was suspended. RESULTS: No new complications were reported. DISCUSSION: Multiple mechanisms are believed to be behind the association between DVT and coeliac disease. However, to this date, no consensus exists regarding the ideal duration of anticoagulation. LEARNING POINTS: Coeliac disease should always be considered a systemic disease. Thromboembolism is a possible extraintestinal manifestation of coeliac disease. Coeliac disease should be considered as a possible cause of thromboembolism even in the absence of gastrointestinal symptoms, which it can precede by several years. SMC Media Srl 2023-08-18 /pmc/articles/PMC10482128/ /pubmed/37680785 http://dx.doi.org/10.12890/2023_003977 Text en © EFIM 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Article
Miranda, Sofia
Clara, Patrícia
Rua, Joana
Cimbron, Miriam
Salvador, Fernando
Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease
title Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease
title_full Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease
title_fullStr Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease
title_full_unstemmed Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease
title_short Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease
title_sort deep vein thrombosis revealing a “silent” coeliac disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482128/
https://www.ncbi.nlm.nih.gov/pubmed/37680785
http://dx.doi.org/10.12890/2023_003977
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