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Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease
INTRODUCTION: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SMC Media Srl
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482128/ https://www.ncbi.nlm.nih.gov/pubmed/37680785 http://dx.doi.org/10.12890/2023_003977 |
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author | Miranda, Sofia Clara, Patrícia Rua, Joana Cimbron, Miriam Salvador, Fernando |
author_facet | Miranda, Sofia Clara, Patrícia Rua, Joana Cimbron, Miriam Salvador, Fernando |
author_sort | Miranda, Sofia |
collection | PubMed |
description | INTRODUCTION: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at the D2 level compatible with coeliac sprue and HLA typing positive for both DQ-2 and DQ-8. METHODS: A gluten free diet was started and apixaban was suspended. RESULTS: No new complications were reported. DISCUSSION: Multiple mechanisms are believed to be behind the association between DVT and coeliac disease. However, to this date, no consensus exists regarding the ideal duration of anticoagulation. LEARNING POINTS: Coeliac disease should always be considered a systemic disease. Thromboembolism is a possible extraintestinal manifestation of coeliac disease. Coeliac disease should be considered as a possible cause of thromboembolism even in the absence of gastrointestinal symptoms, which it can precede by several years. |
format | Online Article Text |
id | pubmed-10482128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SMC Media Srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-104821282023-09-07 Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease Miranda, Sofia Clara, Patrícia Rua, Joana Cimbron, Miriam Salvador, Fernando Eur J Case Rep Intern Med Article INTRODUCTION: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at the D2 level compatible with coeliac sprue and HLA typing positive for both DQ-2 and DQ-8. METHODS: A gluten free diet was started and apixaban was suspended. RESULTS: No new complications were reported. DISCUSSION: Multiple mechanisms are believed to be behind the association between DVT and coeliac disease. However, to this date, no consensus exists regarding the ideal duration of anticoagulation. LEARNING POINTS: Coeliac disease should always be considered a systemic disease. Thromboembolism is a possible extraintestinal manifestation of coeliac disease. Coeliac disease should be considered as a possible cause of thromboembolism even in the absence of gastrointestinal symptoms, which it can precede by several years. SMC Media Srl 2023-08-18 /pmc/articles/PMC10482128/ /pubmed/37680785 http://dx.doi.org/10.12890/2023_003977 Text en © EFIM 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Article Miranda, Sofia Clara, Patrícia Rua, Joana Cimbron, Miriam Salvador, Fernando Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease |
title | Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease |
title_full | Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease |
title_fullStr | Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease |
title_full_unstemmed | Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease |
title_short | Deep Vein Thrombosis Revealing A “Silent” Coeliac Disease |
title_sort | deep vein thrombosis revealing a “silent” coeliac disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482128/ https://www.ncbi.nlm.nih.gov/pubmed/37680785 http://dx.doi.org/10.12890/2023_003977 |
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