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Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region

The insulator model explains the workings of the H19 and Igf2 imprinted domain in the soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the maternally inherited unmethylated chromosome but not the paternally inherited methylated allele. The molecular mechanism that tar...

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Detalles Bibliográficos
Autores principales:	Liao, Ji, Song, Sangmin, Gusscott, Samuel, Fu, Zhen, VanderKolk, Ivan, Busscher, Brianna M., Lau, Kin H., Brind’Amour, Julie, Szabó, Piroska E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482337/ https://www.ncbi.nlm.nih.gov/pubmed/37672574 http://dx.doi.org/10.1126/sciadv.adi2050

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