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Avidity-based biosensors for ubiquitylated PCNA reveal choreography of DNA damage bypass

In eukaryotes, the posttranslational modifier ubiquitin is used to regulate the amounts, interactions, or activities of proteins in diverse pathways and signaling networks. Its effects are mediated by monoubiquitin or polyubiquitin chains of varying geometries. We describe the design, validation, an...

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Detalles Bibliográficos
Autores principales:	Yakoub, George, Choi, Yun-Seok, Wong, Ronald P., Strauch, Tina, Ann, Kezia J., Cohen, Robert E., Ulrich, Helle D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482348/ https://www.ncbi.nlm.nih.gov/pubmed/37672592 http://dx.doi.org/10.1126/sciadv.adf3041

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