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Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level

Bacteria live in complex polymicrobial communities and are constantly competing for resources. The type VI secretion system (T6SS) is a widespread antagonistic mechanism used by Gram-negative bacteria to gain an advantage over competitors. T6SSs translocate toxic effector proteins inside target prok...

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Autores principales: Hespanhol, Julia Takuno, Nóbrega-Silva, Luize, Bayer-Santos, Ethel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482370/
https://www.ncbi.nlm.nih.gov/pubmed/37552221
http://dx.doi.org/10.1099/mic.0.001376
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author Hespanhol, Julia Takuno
Nóbrega-Silva, Luize
Bayer-Santos, Ethel
author_facet Hespanhol, Julia Takuno
Nóbrega-Silva, Luize
Bayer-Santos, Ethel
author_sort Hespanhol, Julia Takuno
collection PubMed
description Bacteria live in complex polymicrobial communities and are constantly competing for resources. The type VI secretion system (T6SS) is a widespread antagonistic mechanism used by Gram-negative bacteria to gain an advantage over competitors. T6SSs translocate toxic effector proteins inside target prokaryotic cells in a contact-dependent manner. In addition, some T6SS effectors can be secreted extracellularly and contribute to the scavenging scarce metal ions. Bacteria deploy their T6SSs in different situations, categorizing these systems into offensive, defensive and exploitative. The great variety of bacterial species and environments occupied by such species reflect the complexity of regulatory signals and networks that control the expression and activation of the T6SSs. Such regulation is tightly controlled at the transcriptional, posttranscriptional and posttranslational level by abiotic (e.g. pH, iron) or biotic (e.g. quorum-sensing) cues. In this review, we provide an update on the current knowledge about the regulatory networks that modulate the expression and activity of T6SSs across several species, focusing on systems used for interbacterial competition.
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spelling pubmed-104823702023-09-07 Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level Hespanhol, Julia Takuno Nóbrega-Silva, Luize Bayer-Santos, Ethel Microbiology (Reading) Reviews Bacteria live in complex polymicrobial communities and are constantly competing for resources. The type VI secretion system (T6SS) is a widespread antagonistic mechanism used by Gram-negative bacteria to gain an advantage over competitors. T6SSs translocate toxic effector proteins inside target prokaryotic cells in a contact-dependent manner. In addition, some T6SS effectors can be secreted extracellularly and contribute to the scavenging scarce metal ions. Bacteria deploy their T6SSs in different situations, categorizing these systems into offensive, defensive and exploitative. The great variety of bacterial species and environments occupied by such species reflect the complexity of regulatory signals and networks that control the expression and activation of the T6SSs. Such regulation is tightly controlled at the transcriptional, posttranscriptional and posttranslational level by abiotic (e.g. pH, iron) or biotic (e.g. quorum-sensing) cues. In this review, we provide an update on the current knowledge about the regulatory networks that modulate the expression and activity of T6SSs across several species, focusing on systems used for interbacterial competition. Microbiology Society 2023-08-08 /pmc/articles/PMC10482370/ /pubmed/37552221 http://dx.doi.org/10.1099/mic.0.001376 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
spellingShingle Reviews
Hespanhol, Julia Takuno
Nóbrega-Silva, Luize
Bayer-Santos, Ethel
Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level
title Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level
title_full Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level
title_fullStr Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level
title_full_unstemmed Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level
title_short Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level
title_sort regulation of type vi secretion systems at the transcriptional, posttranscriptional and posttranslational level
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482370/
https://www.ncbi.nlm.nih.gov/pubmed/37552221
http://dx.doi.org/10.1099/mic.0.001376
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