Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM

Congenital tufting enteropathy (CTE) is a life-threatening intestinal disorder resulting from loss-of-function mutations in EPCAM and SPINT2. Mice deficient in Spint2, encoding the protease inhibitor HAI-2, develop CTE-like intestinal failure associated with a progressive loss of the EpCAM protein,...

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Detalles Bibliográficos
Autores principales: Szabo, Roman, Kawaguchi, Makiko, Kataoka, Hiroaki, Bugge, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482385/
https://www.ncbi.nlm.nih.gov/pubmed/37539662
http://dx.doi.org/10.1242/dev.201801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482385/
https://www.ncbi.nlm.nih.gov/pubmed/37539662
http://dx.doi.org/10.1242/dev.201801

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