Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles

Recent studies have suggested that CD8(+) liver-resident memory T (T(RM)) cells are crucial in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid nanoparticles (mRNA-LNPs) to induce liver T(RM) cells in a murine model. Single-dose intravenous injections of ovalb...

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Detalles Bibliográficos
Autores principales: Nakamae, Sayuri, Miyagawa, Satoshi, Ogawa, Koki, Kamiya, Mariko, Taniguchi, Mayumi, Ono, Akari, Kawaguchi, Maho, Teklemichael, Awet Alem, Jian, Jiun-Yu, Araki, Tamasa, Katagami, Yukimi, Mukai, Hidefumi, Annoura, Takeshi, Yui, Katsuyuki, Hirayama, Kenji, Kawakami, Shigeru, Mizukami, Shusaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482405/
https://www.ncbi.nlm.nih.gov/pubmed/37680630
http://dx.doi.org/10.3389/fimmu.2023.1116299

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