Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer

Metabolic reprogramming is a phenomenon in which cancer cells alter their metabolic pathways to support their uncontrolled growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic aci...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Jinbowen, Xu, Fangzhi, Zhou, Dan, Zhang, Shuo, Zhang, Bo, Meng, Qingwei, Lv, Qiubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482409/
https://www.ncbi.nlm.nih.gov/pubmed/37681030
http://dx.doi.org/10.3389/fonc.2023.1231460
_version_ 1785102167350181888
author Yan, Jinbowen
Xu, Fangzhi
Zhou, Dan
Zhang, Shuo
Zhang, Bo
Meng, Qingwei
Lv, Qiubo
author_facet Yan, Jinbowen
Xu, Fangzhi
Zhou, Dan
Zhang, Shuo
Zhang, Bo
Meng, Qingwei
Lv, Qiubo
author_sort Yan, Jinbowen
collection PubMed
description Metabolic reprogramming is a phenomenon in which cancer cells alter their metabolic pathways to support their uncontrolled growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle. These changes lead to the creation of metabolic intermediates that can provide precursors for the biosynthesis of cellular components and help maintain cellular energy homeostasis. This article reviews the research progress of the metabolic reprogramming mechanism of platinumbased chemotherapy resistance caused by three major nutrients in ovarian cancer.
format Online
Article
Text
id pubmed-10482409
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104824092023-09-07 Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer Yan, Jinbowen Xu, Fangzhi Zhou, Dan Zhang, Shuo Zhang, Bo Meng, Qingwei Lv, Qiubo Front Oncol Oncology Metabolic reprogramming is a phenomenon in which cancer cells alter their metabolic pathways to support their uncontrolled growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle. These changes lead to the creation of metabolic intermediates that can provide precursors for the biosynthesis of cellular components and help maintain cellular energy homeostasis. This article reviews the research progress of the metabolic reprogramming mechanism of platinumbased chemotherapy resistance caused by three major nutrients in ovarian cancer. Frontiers Media S.A. 2023-08-22 /pmc/articles/PMC10482409/ /pubmed/37681030 http://dx.doi.org/10.3389/fonc.2023.1231460 Text en Copyright © 2023 Yan, Xu, Zhou, Zhang, Zhang, Meng and Lv https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yan, Jinbowen
Xu, Fangzhi
Zhou, Dan
Zhang, Shuo
Zhang, Bo
Meng, Qingwei
Lv, Qiubo
Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer
title Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer
title_full Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer
title_fullStr Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer
title_full_unstemmed Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer
title_short Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer
title_sort metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482409/
https://www.ncbi.nlm.nih.gov/pubmed/37681030
http://dx.doi.org/10.3389/fonc.2023.1231460
work_keys_str_mv AT yanjinbowen metabolicreprogrammingofthreemajornutrientsinplatinumresistantovariancancer
AT xufangzhi metabolicreprogrammingofthreemajornutrientsinplatinumresistantovariancancer
AT zhoudan metabolicreprogrammingofthreemajornutrientsinplatinumresistantovariancancer
AT zhangshuo metabolicreprogrammingofthreemajornutrientsinplatinumresistantovariancancer
AT zhangbo metabolicreprogrammingofthreemajornutrientsinplatinumresistantovariancancer
AT mengqingwei metabolicreprogrammingofthreemajornutrientsinplatinumresistantovariancancer
AT lvqiubo metabolicreprogrammingofthreemajornutrientsinplatinumresistantovariancancer

Ejemplares similares