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Combined α(2)- and D(2)-receptor blockade activates noradrenergic and dopaminergic neurons, but extracellular dopamine in the prefrontal cortex is determined by uptake and release from noradrenergic terminals
Experimental and clinical evidence indicates a deficit of release and function of dopamine in schizophrenia and suggests that α(2)-adrenoceptor antagonists rescue dopamine deficit and improve the antipsychotic efficacy of D(2)-receptor antagonists. In anesthetized male rats, we investigated how the...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482411/ https://www.ncbi.nlm.nih.gov/pubmed/37680715 http://dx.doi.org/10.3389/fphar.2023.1238115 |