Cargando…

Protecting the heart

Blocking a protein known as EPAC1 may prevent the development of heart-related side effects caused by a chemotherapy drug.

Detalles Bibliográficos
Autores principales:	Inglis, Joshua M, Mangoni, Arduino A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482425/ https://www.ncbi.nlm.nih.gov/pubmed/37672034 http://dx.doi.org/10.7554/eLife.91831

Ejemplares similares

EPAC1 inhibition protects the heart from doxorubicin-induced toxicity
por: Mazevet, Marianne, et al.
Publicado: (2023)

Targeting LMW‐PTP to sensitize melanoma cancer cells toward chemo‐ and radiotherapy
por: Lori, Giulia, et al.
Publicado: (2018)

Fishing for protective compounds
por: Ciarimboli, Giuliano
Publicado: (2020)

Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation
por: Blake, Sophia M, et al.
Publicado: (2016)

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
por: LoCoco, Peter M, et al.
Publicado: (2017)

Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity
por: Abedi, Marjan, et al.
Publicado: (2020)

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
por: Nassar, Zeyad D, et al.
Publicado: (2020)

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model
por: Wertman, Jaime N, et al.
Publicado: (2020)

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
por: Balasubramanian, Sandhya, et al.
Publicado: (2022)

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells
por: Javidi-Sharifi, Nathalie, et al.
Publicado: (2019)

Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells
por: Javidi-Sharifi, Nathalie, et al.
Publicado: (2019)

IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis
por: Rothe, Michael, et al.
Publicado: (2013)

Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor‐induced senescence in breast cancer cells
por: Kartika, Irna D., et al.
Publicado: (2021)

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia
por: Hatterschide, Joshua, et al.
Publicado: (2022)

Shifting the focus of zebrafish toward a model of the tumor microenvironment
por: Weiss, Joshua M, et al.
Publicado: (2022)

Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma
por: Cheng, Chun-Chun, et al.
Publicado: (2020)

Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization
por: Greenlee, Joshua D, et al.
Publicado: (2021)

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair
por: Jimenez-Sainz, Judit, et al.
Publicado: (2022)

Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma
por: Ben‐Dayan, Miriam M., et al.
Publicado: (2017)

Geriatric Medicine in an Aging Society: Up for a Challenge?
por: Mangoni, Arduino A.
Publicado: (2014)

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor
por: Mounir, Zineb, et al.
Publicado: (2016)

Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3
por: Klover, Peter J, et al.
Publicado: (2017)

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer
por: Shah, Neel, et al.
Publicado: (2017)

Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
por: Errington, Timothy M, et al.
Publicado: (2021)

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy
por: Cui, Xin, et al.
Publicado: (2020)

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy
por: Springer, Simeon U, et al.
Publicado: (2018)

Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy
por: Springer, Simeon U, et al.
Publicado: (2018)

Making sense of replications
por: Nosek, Brian A, et al.
Publicado: (2017)

LINC00857 expression predicts and mediates the response to platinum‐based chemotherapy in muscle‐invasive bladder cancer
por: Dudek, Aleksandra M., et al.
Publicado: (2018)

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis
por: Schwager, Samantha C, et al.
Publicado: (2022)

The regulation of tumor‐suppressive microRNA, miR‐126, in chronic lymphocytic leukemia
por: Guinn, Daphne, et al.
Publicado: (2017)

Molecular heterogeneity in human papillomavirus‐dependent and ‐independent vulvar carcinogenesis
por: Swarts, Dorian R. A., et al.
Publicado: (2018)

Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells
por: Cavassani, Karen A., et al.
Publicado: (2018)

Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations
por: Porter, Shaina N, et al.
Publicado: (2016)

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
por: Shemorry, Anna, et al.
Publicado: (2019)

Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors
por: Cittelly, Diana M., et al.
Publicado: (2010)

Challenges for assessing replicability in preclinical cancer biology
por: Errington, Timothy M, et al.
Publicado: (2021)

PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer
por: Barber, Alison G, et al.
Publicado: (2015)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

A window-of-opportunity biomarker study of etodolac in resectable breast cancer
por: Schwab, Richard B, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_nkgrplb53oaulhh8fj3amhnvbj