RAIDS atlas of significant genetic and protein biomarkers in cervical cancer

Loss of function in epigenetic acting genes together with driver alterations in the PIK3CA pathway have been shown significantly associated with poor outcome in cervical squamous cell cancer. More recently, a CoxBoost analysis identified 16 gene alterations and 30 high level activated proteins to be...

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Detalles Bibliográficos
Autores principales: Scholl, Suzy, Roufai, Diana Bello, Chérif, Linda Larbi, Kamal, Maud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482580/
https://www.ncbi.nlm.nih.gov/pubmed/37668079
http://dx.doi.org/10.3802/jgo.2023.34.e74
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author Scholl, Suzy
Roufai, Diana Bello
Chérif, Linda Larbi
Kamal, Maud
author_facet Scholl, Suzy
Roufai, Diana Bello
Chérif, Linda Larbi
Kamal, Maud
author_sort Scholl, Suzy
collection PubMed
description Loss of function in epigenetic acting genes together with driver alterations in the PIK3CA pathway have been shown significantly associated with poor outcome in cervical squamous cell cancer. More recently, a CoxBoost analysis identified 16 gene alterations and 30 high level activated proteins to be of high interest, due to their association with either good or bad outcome, in the context of treatment received by chemoradiation. The objectives here were to review and confirm the significance of these molecular alterations as suggested by literature reports and to pinpoint alternate treatments options for poor-responders to chemoradiation.
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spelling pubmed-104825802023-09-08 RAIDS atlas of significant genetic and protein biomarkers in cervical cancer Scholl, Suzy Roufai, Diana Bello Chérif, Linda Larbi Kamal, Maud J Gynecol Oncol Review Article Loss of function in epigenetic acting genes together with driver alterations in the PIK3CA pathway have been shown significantly associated with poor outcome in cervical squamous cell cancer. More recently, a CoxBoost analysis identified 16 gene alterations and 30 high level activated proteins to be of high interest, due to their association with either good or bad outcome, in the context of treatment received by chemoradiation. The objectives here were to review and confirm the significance of these molecular alterations as suggested by literature reports and to pinpoint alternate treatments options for poor-responders to chemoradiation. Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 2023-08-18 /pmc/articles/PMC10482580/ /pubmed/37668079 http://dx.doi.org/10.3802/jgo.2023.34.e74 Text en © 2023. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Scholl, Suzy
Roufai, Diana Bello
Chérif, Linda Larbi
Kamal, Maud
RAIDS atlas of significant genetic and protein biomarkers in cervical cancer
title RAIDS atlas of significant genetic and protein biomarkers in cervical cancer
title_full RAIDS atlas of significant genetic and protein biomarkers in cervical cancer
title_fullStr RAIDS atlas of significant genetic and protein biomarkers in cervical cancer
title_full_unstemmed RAIDS atlas of significant genetic and protein biomarkers in cervical cancer
title_short RAIDS atlas of significant genetic and protein biomarkers in cervical cancer
title_sort raids atlas of significant genetic and protein biomarkers in cervical cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482580/
https://www.ncbi.nlm.nih.gov/pubmed/37668079
http://dx.doi.org/10.3802/jgo.2023.34.e74
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