4-phenylbutyric acid re-trafficking hERG/G572R channel protein by modulating the endoplasmic reticulum stress-associated chaperones and endoplasmic reticulum-associated degradation gene

BACKGROUND: Long QT syndrome type 2 (LQT2) is caused by mutations in the KCNH2/human ether-à-go-go-related gene (hERG). Some hERG genetic mutation-associated diseases are alleviated by hERG-specific drug chaperones (glycerol, dimethyl sulfoxide, trimethylamine N-oxide, thapsigargin), delayed rectifi...

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Detalles Bibliográficos
Autores principales: Tang, Wen, Cai, Dihui, Fu, Yin, Zheng, Zequn, Huang, Xiaoyan, Khouzam, Rami N., Song, Yongfei, Lian, Jiangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482650/
https://www.ncbi.nlm.nih.gov/pubmed/37691654
http://dx.doi.org/10.21037/jtd-23-1252

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