Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers

Homologous recombination (HR) deficiency is associated with DNA rearrangements and cytogenetic aberrations(1). Paradoxically, the types of DNA rearrangements that are specifically associated with HR-deficient cancers only minimally affect chromosomal structure(2). Here, to address this apparent cont...

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Detalles Bibliográficos
Autores principales: Setton, Jeremy, Hadi, Kevin, Choo, Zi-Ning, Kuchin, Katherine S., Tian, Huasong, Da Cruz Paula, Arnaud, Rosiene, Joel, Selenica, Pier, Behr, Julie, Yao, Xiaotong, Deshpande, Aditya, Sigouros, Michael, Manohar, Jyothi, Nauseef, Jones T., Mosquera, Juan-Miguel, Elemento, Olivier, Weigelt, Britta, Riaz, Nadeem, Reis-Filho, Jorge S., Powell, Simon N., Imieliński, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482687/
https://www.ncbi.nlm.nih.gov/pubmed/37587346
http://dx.doi.org/10.1038/s41586-023-06461-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482687/
https://www.ncbi.nlm.nih.gov/pubmed/37587346
http://dx.doi.org/10.1038/s41586-023-06461-2

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