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Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults

BACKGROUND: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults. METHODS: We aimed to investigate the association between long-term ozone exposure and lung function decli...

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Autores principales: Zhao, Tianyu, Markevych, Iana, Fuertes, Elaine, de Hoogh, Kees, Accordini, Simone, Boudier, Anne, Casas, Lidia, Forsberg, Bertil, Garcia Aymerich, Judith, Gnesi, Marco, Holm, Mathias, Janson, Christer, Jarvis, Deborah, Johannessen, Ane, Jörres, Rudolf A., Karrasch, Stefan, Leynaert, Benedicte, Maldonado Perez, José Antonio, Malinovschi, Andrei, Martínez-Moratalla, Jesús, Modig, Lars, Nowak, Dennis, Potts, James, Probst-Hensch, Nicole, Sánchez-Ramos, José Luis, Siroux, Valerie, Urrutia Landa, Isabel, Vienneau, Danielle, Villani, Simona, Jacquemin, Bénédicte, Heinrich, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482740/
https://www.ncbi.nlm.nih.gov/pubmed/37691742
http://dx.doi.org/10.1016/j.lanepe.2023.100729
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author Zhao, Tianyu
Markevych, Iana
Fuertes, Elaine
de Hoogh, Kees
Accordini, Simone
Boudier, Anne
Casas, Lidia
Forsberg, Bertil
Garcia Aymerich, Judith
Gnesi, Marco
Holm, Mathias
Janson, Christer
Jarvis, Deborah
Johannessen, Ane
Jörres, Rudolf A.
Karrasch, Stefan
Leynaert, Benedicte
Maldonado Perez, José Antonio
Malinovschi, Andrei
Martínez-Moratalla, Jesús
Modig, Lars
Nowak, Dennis
Potts, James
Probst-Hensch, Nicole
Sánchez-Ramos, José Luis
Siroux, Valerie
Urrutia Landa, Isabel
Vienneau, Danielle
Villani, Simona
Jacquemin, Bénédicte
Heinrich, Joachim
author_facet Zhao, Tianyu
Markevych, Iana
Fuertes, Elaine
de Hoogh, Kees
Accordini, Simone
Boudier, Anne
Casas, Lidia
Forsberg, Bertil
Garcia Aymerich, Judith
Gnesi, Marco
Holm, Mathias
Janson, Christer
Jarvis, Deborah
Johannessen, Ane
Jörres, Rudolf A.
Karrasch, Stefan
Leynaert, Benedicte
Maldonado Perez, José Antonio
Malinovschi, Andrei
Martínez-Moratalla, Jesús
Modig, Lars
Nowak, Dennis
Potts, James
Probst-Hensch, Nicole
Sánchez-Ramos, José Luis
Siroux, Valerie
Urrutia Landa, Isabel
Vienneau, Danielle
Villani, Simona
Jacquemin, Bénédicte
Heinrich, Joachim
author_sort Zhao, Tianyu
collection PubMed
description BACKGROUND: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults. METHODS: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM(2.5), NO(2), and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age. FINDINGS: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV(1) of −2.08 mL/year (95% confidence interval: −2.79, −1.36) and in FVC of −2.86 mL/year (−3.73, −1.99) mL/year over the study period. Associations were robust after adjusting for PM(2.5), NO(2), and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV(1)/FVC ratio. INTERPRETATION: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period. FUNDING: 10.13039/501100001659German Research Foundation.
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spelling pubmed-104827402023-09-08 Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults Zhao, Tianyu Markevych, Iana Fuertes, Elaine de Hoogh, Kees Accordini, Simone Boudier, Anne Casas, Lidia Forsberg, Bertil Garcia Aymerich, Judith Gnesi, Marco Holm, Mathias Janson, Christer Jarvis, Deborah Johannessen, Ane Jörres, Rudolf A. Karrasch, Stefan Leynaert, Benedicte Maldonado Perez, José Antonio Malinovschi, Andrei Martínez-Moratalla, Jesús Modig, Lars Nowak, Dennis Potts, James Probst-Hensch, Nicole Sánchez-Ramos, José Luis Siroux, Valerie Urrutia Landa, Isabel Vienneau, Danielle Villani, Simona Jacquemin, Bénédicte Heinrich, Joachim Lancet Reg Health Eur Articles BACKGROUND: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults. METHODS: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM(2.5), NO(2), and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age. FINDINGS: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV(1) of −2.08 mL/year (95% confidence interval: −2.79, −1.36) and in FVC of −2.86 mL/year (−3.73, −1.99) mL/year over the study period. Associations were robust after adjusting for PM(2.5), NO(2), and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV(1)/FVC ratio. INTERPRETATION: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period. FUNDING: 10.13039/501100001659German Research Foundation. Elsevier 2023-09-01 /pmc/articles/PMC10482740/ /pubmed/37691742 http://dx.doi.org/10.1016/j.lanepe.2023.100729 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Articles
Zhao, Tianyu
Markevych, Iana
Fuertes, Elaine
de Hoogh, Kees
Accordini, Simone
Boudier, Anne
Casas, Lidia
Forsberg, Bertil
Garcia Aymerich, Judith
Gnesi, Marco
Holm, Mathias
Janson, Christer
Jarvis, Deborah
Johannessen, Ane
Jörres, Rudolf A.
Karrasch, Stefan
Leynaert, Benedicte
Maldonado Perez, José Antonio
Malinovschi, Andrei
Martínez-Moratalla, Jesús
Modig, Lars
Nowak, Dennis
Potts, James
Probst-Hensch, Nicole
Sánchez-Ramos, José Luis
Siroux, Valerie
Urrutia Landa, Isabel
Vienneau, Danielle
Villani, Simona
Jacquemin, Bénédicte
Heinrich, Joachim
Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
title Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
title_full Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
title_fullStr Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
title_full_unstemmed Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
title_short Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
title_sort impact of long-term exposure to ambient ozone on lung function over a course of 20 years (the ecrhs study): a prospective cohort study in adults
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482740/
https://www.ncbi.nlm.nih.gov/pubmed/37691742
http://dx.doi.org/10.1016/j.lanepe.2023.100729
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