Targeting ACC1 in T cells ameliorates psoriatic skin inflammation

ABSTRACT: Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including T helper (Th) and cytotoxic T (Tc) cells, and is associated with dysfunctional regulatory T cells (Tregs). Acetyl-CoA carboxylase 1 (ACC1), a...

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Detalles Bibliográficos
Autores principales: Kao, Yu-San, Mamareli, Panagiota, Dhillon-LaBrooy, Ayesha, Stüve, Philipp, Godoy, Gloria Janet, Velasquez, Lis Noelia, Raker, Verena Katharina, Weidenthaler-Barth, Beate, Boukhallouk, Fatima, Rampoldi, Francesca, Berod, Luciana, Sparwasser, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482807/
https://www.ncbi.nlm.nih.gov/pubmed/37594540
http://dx.doi.org/10.1007/s00109-023-02349-w

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